Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCF nanotechnology may speed up drug testing

20.12.2011
Testing the effectiveness of new pharmaceuticals may get faster thanks to a new technique incorporating quantum dots developed at the University of Central Florida.

Some drug testing can take a decade or more, but UCF associate professor Swadeshmukul Santra and his team have created an electronic quantum dots (Qdots) probe that "lights up" when a drug it is delivering attaches to cancer cells. The research appears online in this month's Biomaterials. http://www.sciencedirect.com/science/article/pii/S0142961211012841#FCANote

A researcher can use a microscope to see where and how much of the drug has been delivered because the probe emits a reddish color under special lighting or via MRI because of its optical and magnetic components.

As the drug testing continues, images can be taken over and over without any loss of optical or MRI signal. Researchers can then measure the size of the tumor and number of cancer cells that "light up" compared with the original untreated tumor.

This provides a way to determine whether the drug is doing what it is supposed to be doing in the targeted areas. The technique is much easier than the current process of removing treated cancer tumors and weighing them at regular intervals to determine the drug's efficiency in an animal.

"Many people in my area have been studying this approach for years," Santra said. "But we have now moved it into a live cell, not just in test tubes."

Sudiptal Seal, the director of UCF's NanoScience Technology Center and nanoscience scientist believes Santra's research is significant.

"This is indeed a major breakthrough in Qdot research," Seal said. "This new diagnostic tool will certainly impact the field of nanomedicine."

Santra and his team used semiconductor Qdots to create the probe. Because of their small size and crystal-like structure, Qdots display unique optical and electronic properties when they get excited. These unique properties make them ideal for sustained and reliable imaging with special lights.

For this research funded by the National Science Foundation and National Institutes of Health, the UCF-led team used a superparamagnetic iron oxide nanoparticle core decorated with satellite CdS:Mn/ZnS Qdots which carried the cancer-fighting agent STAT3 inhibitor. The Qdot optical signal turned on when the probe bonded with the cancer cells.

"The potential applications for drug testing specifically for cancer research are immediate," Santra said.

Collaborators on the research included: Andre J. Gesquiere also of UCF, James Turkson of the University of Hawaii, Glenn A. Water of the University of Florida and Patrick T. Gunning from the University of Toronto.

Santra has his own team of students and scientists at the UCF NanoScience Technology Center, which has been studying nanotechnology, quantum dots and their applications for years. The team focuses on the engineering of nanomaterials for bioimaging and sensing, drug delivery and anti-microbial applications.

Santra joined UCF in 2005 after working as a research assistant professor at the University of Florida. He has a Ph.D. from the Indian Institute of Technology Kanpur and served as a postdoctoral fellow at the University of Florida. He has written dozens of articles and book chapters on nanoscience and nanotechnology. Santra also holds eight US patents in nano-bio and biomedical fields.

CONTACT: Zenaida Gonzalez Kotala, UCF News & Information, 407-823-6120 or zenaida.kotala@ucf.edu

UCF Stands For Opportunity --The University of Central Florida is a metropolitan research university that ranks as the second largest in the nation with more than 58,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy. For more information visit http://news.ucf.edu

Zenaida Kotala | EurekAlert!
Further information:
http://www.ucf.edu

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>