Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The inhibition of a protein opens the door to the treatment of pancreatic cancer, one of the tumours with the worst prognosis

01.07.2014

The inhibition of a protein opens the door to the treatment of pancreatic cancer, one of the tumours with the worst prognosis

Researchers from IMIM (Hospital del Mar Medical Research Institute) have identified a new protein, galectin-1, as a possible therapeutic target for pancreatic cancer. For the first time they have demonstrated the effects of the inhibition of this protein in mice suffering this type of cancer and the results showed an increase in survival of 20%. The work further suggests that it could be a therapeutic target with no adverse effects.

Until now, the strategies for treating this tumour were aimed at attacking the tumour cells and had little success. The latest studies indicate that trying to destroy what surrounds the tumour is possibly a better strategy. “Our contribution is directed toward this, as the reduction of galectin-1 mainly affects the immune system and the cells and structure that surrounds the tumour cells, which is called the stroma. Therefore, galectin-1 as a therapeutic target has great potential”, explains Dr. Pilar Navarro, co-ordinator of the research group on molecular mechanisms of tumorigenesis of IMIM and director of the research.

It was known that galectin-1 was not found in the normal pancreas despite being strongly expressed in pancreatic tumours. Furthermore, some clear functions were known which demonstrate the relationship between galectin-1 and tumour progression in other contexts. In fact, some preclinical studies for other diseases use inhibitor molecules and antibodies against this protein. “We are aiming at its possible use in pancreatic cancer” states Dr. Neus Martínez, researcher of the group on molecular mechanisms and tumorigenesis of IMIM and first author of this article. “We have also observed that the elimination of galectin-1 in mice has no harmful consequences, indicating that it could be a safe therapeutic target with no adverse effects”, she adds.

In collaboration with the Hospital del Mar Anatomical Pathology Service, which has analysed some samples, pancreatic tumours were studied in mice with high levels of galectin-1 and after its depletion. They observed that tumours without this protein showed less proliferation, fewer blood vessels, less inflammation and an increase in the immune response. All these changes are associated with less aggressive tumours.

Pancreatic cancer is one of the tumours with the worst prognosis, with a survival rate of less than 2%, 5 years after diagnosis. Although it is not a very common tumour, it is the fourth cause of cancer-related death in developed countries. This is due, on one hand, to the fact that it is often diagnosed too late, when the tumour has already metastasised and, on the other hand, to the inefficacy of current treatments. In Spain 4000 cases are diagnosed each year. Although it is a tumour that is well known at molecular level, its diagnosis and treatment are still one step behind. In fact it is one of the tumours with the least therapeutic advancements in recent years.

The results are very encouraging but we must be prudent as there are many factors to take into account. The researchers now want to move the results obtained to preclinical studies, where they will treat mice with pancreatic cancer with chemical inhibitors or antibodies against galectin-1 (the same treatment that would be used for a cancer patient) in order to verify the therapeutic utility of this target. In the event that they obtain positive results and manage to halt the tumour, the next step would be to propose its use on patients. Obviously we are talking about long-term objectives, as the transfer of studies on animals to humans is usually a slow process.

Reference article:

Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation. Neus Martinez-Bosch, Maite G Fernandez-Barrena, Mireia Moreno, Elena Ortiz-Zapater, Jessica Munné-Collado, Mar Iglesias, Sabine André, Hans-Joachim Gabius, Rosa F. Hwang, Françoise Poirier, Carolina Navas, Carmen Guerra, Martin E. Fernández-Zapico, and Pilar Navarro. Cancer Res. Doi:10.1158/0008-5472.CAN-13-3013

Marta Calsina | Eurek Alert!
Further information:
http://www.imim.es/news/184/the-inhibition-of-a-protein-opens-the-door-to-the-treatment-of-pancreatic-cancer-one-of-the-tumours-with-the-worst-prognosis

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>