Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Temperature rhythms keep body clocks in sync

15.10.2010
Researchers at UT Southwestern Medical Center have found that fluctuations in internal body temperature regulate the body's circadian rhythm, the 24-hour cycle that controls metabolism, sleep and other bodily functions.

A light-sensitive portion of the brain called the suprachiasmatic nucleus (SCN) remains the body's "master clock" that coordinates the daily cycle, but it does so indirectly, according to a study published by UT Southwestern researchers in the Oct. 15 issue of Science.

The SCN responds to light entering the eye, and so is sensitive to cycles of day and night. While light may be the trigger, the UT Southwestern researchers determined that the SCN transforms that information into neural signals that set the body's temperature. These cyclic fluctuations in temperature then set the timing of cells, and ultimately tissues and organs, to be active or inactive, the study showed.

Scientists have long known that body temperature fluctuates in warm-blooded animals throughout the day on a 24-hour, or circadian, rhythm, but the new study shows that temperature actually controls body cycles, said Dr. Joseph Takahashi, chairman of neuroscience at UT Southwestern and senior author of the study.

"Small changes in body temperature can send a powerful signal to the clocks in our bodies," said Dr. Takahashi, an investigator with the Howard Hughes Medical Institute. "It takes only a small change in internal body temperature to synchronize cellular 'clocks' throughout the body."

Daily changes in temperature span only a few degrees and stay within normal healthy ranges. This mechanism has nothing to do with fever or environmental temperature, Dr. Takahashi said.

This system might be a modification of an ancient circadian control system that first developed in other organisms, including cold-blooded animals, whose daily biological cycles are affected by external temperature changes, Dr. Takahashi said.

"Circadian rhythms in plants, simple organisms and cold-blooded animals are very sensitive to temperature, so it makes sense that over the course of evolution, this primordial mechanism could have been modified in warm-blooded animals," he said.

In the current study, the researchers focused on cultured mouse cells and tissues, and found that genes related to circadian functions were controlled by temperature fluctuations.

SCN cells were not temperature-sensitive, however. This finding makes sense, Dr. Takahashi said, because if the SCN, as the master control mechanism, responded to temperature cues, a disruptive feedback loop could result, he said.

Dr. Seung-Hee Yoo, instructor of neuroscience, and former graduate student Ethan Buhr also participated in the investigation.

The study was funded by the National Institutes of Health and the HHMI.

This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via e-mail, subscribe at www.utsouthwestern.edu/receivenews

Aline McKenzie | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>