Crops and other plants are constantly confronted with adverse environmental conditions, lowering yield and costing farmers billions of dollars annually. Plants use specialized signals, called stress hormones, to sense difficult times and adapt to stressful conditions to enhance survival.
Of the various stress hormones, abscisic acid (ABA), produced naturally by plants, has emerged over the last 30 years as the key hormone that helps plants cope with drought conditions. Under such stress, plants increase their ABA levels, which helps them survive the drought through a process not fully understood. So critical is this endogenous chemical to plant survival that researchers have engineered new drought-resistant crops by tinkering with the ABA pathway.For years, scientists have contemplated spraying ABA directly onto crops to enhance their protection in times of stress. But ABA is a costly, complicated and light-sensitive molecule that has not found use in agriculture.
Using a method called chemical genomics, pioneered by UC Riverside researchers for studying plant biology, Cutler identified pyrabactin, a new synthetic chemical that turns on the ABA signaling pathway in Arabidopsis, a small flowering plant used widely in plant biology laboratories as a model organism.His lab then used pyrabactin to fish out a receptor for ABA – a highly controversial topic involving retractions of scientific papers as well as the publication of papers of questionable significance. A receptor is a protein molecule in a cell to which mobile signaling molecules may attach. Usually at the top of a signaling pathway, it functions like a boss relaying orders to the team below that then executes particular decisions in the cell.
Cutler's approach highlights the power of the chemical genetic approach for uncovering new leads for agrichemistry and, in turn, using those leads to understand a biological process.
"This is a striking example of how a chemical allowed us to solve a problem that genetics has been struggling with," he said. "Clearly, chemical genetics can be used to bypass some of the limitations that slow down classical genetic analysis. Not too long ago, the United Nations called for a 'blue revolution' - the water equivalent of the green revolution - of improved water management and sharing. We have proven that we can enlist chemicals that modulate stress responses in crops as soldiers in the blue revolution. Now our goal is to design the best chemical soldiers possible."
Study results appear April 30 in Science Express and in the May 22 issue of Science magazine.
Because of the prior questionable data in the ABA field, Cutler, the research paper's lead author, took the unusual step of sharing his data with key competitors and turning them into collaborators before publishing the results. Several labs working in the ABA signaling field tested the ABA receptor that Cutler's group identified, and validated his results. Scientists from these labs are co-authors of the research paper.
"Several high-profile papers have tried to claim discovery of ABA receptors but their research could not stand the test of time, and these papers were ultimately withdrawn," said Natasha Raikhel, the director of UCR's Center for Plant Cell Biology, of which Cutler is a member. "I believe this time, Dr. Cutler and his team have isolated a true ABA receptor."
Next in the research, Cutler and collaborator Brian Volkman of the Medical College of Wisconsin will work on deducing the structure of receptor-bound ABA and use this information to guide the design of new chemicals that turn on the ABA signaling pathway. Cutler and collaborators also plan to further understand how the ABA receptors affect plant physiology.
Cutler was joined in the research by colleagues at UCR; the University of Toronto, Canada; UC San Diego; Universidad Politecnica, Spain; University of Ontario Institute of Technology, Canada; UC Santa Barbara; and the Medical College of Wisconsin.
Grants from the Canadian Research Chair, the Natural Sciences and Engineering Research Council (Canada), the National Science Foundation and the National Institutes of Health funded the five-year study.The University of California, Riverside is a doctoral research university, a living laboratory for groundbreaking exploration of issues critical to Inland Southern California, the state and communities around the world. Reflecting California's diverse culture, UCR's enrollment of about 17,000 is expected to grow to 21,000 students by 2020. The campus is planning a medical school and has reached the heart of the Coachella Valley by way of the UCR Palm Desert Graduate Center. The campus has an annual statewide economic impact of more than $1 billion. To learn more, visit www.ucr.edu or call (951) UCR-NEWS.
Iqbal Pittalwala | EurekAlert!
Further reports about: > Medical Wellness > Plants > Science TV > UCR > abscisic acid > blue revolution > crops > crops facing drought > drought-resistant crops > plant cell biology > pyrabactin mimics hormone > signaling pathway > stress hormone > stress hormones > stress tolerance > stressful conditions > synthetic biology
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences