Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New sleep cycle discovery explains why fatty diets during pregnancy make kids obese

23.11.2010
New research in the FASEB Journal suggests that a fetal liver gene called Npas2 is a key regulator of the circadian system with a significant metabolic response as a result of a mother's high-fat diet

The link between sleeping and obesity is drawn tighter as a new research published online in the FASEB Journal (http://www.fasebj.org/content/early/2010/11/19/fj.10-172080.abstract) study shows that what your mother ate when she was pregnant may make you obese or overweight by altering the function of genes (epigenetic changes) that regulate circadian rhythm. In the report, pregnant primate females consuming a high-fat diet altered the function of fetal genes that regulate circadian rhythm (including appetite and food intake) during development. The offspring also had non-alcoholic fatty liver disease.

"It is our hope that our studies will continue to guide research aimed at understanding the pivotal role that maternal health plays in guiding the health of the next generation," said Kjersti Aagaard-Tillery, M.D., Ph.D., a researcher involved in the work from the Department of Obstetrics and Gynecology at Baylor College of Medicine in Houston. "We are enthusiastic that our research will give hope that even small changes, such as improving one's diet in pregnancy and during breastfeeding, will translate into a lower chance for obesity in our next generation."

To make this discovery, Aagaard-Tillery and colleagues studied three groups of Japanese macaque primates. One group was fed a 12 percent fat diet (the control group). The second group was fed a 35 percent fat or high-fat diet and the third group was fed the high-fat diet for up to five years and then switched back to the control diet. Each group maintained their specific diet prior to conception and throughout pregnancy. Offspring from the high-fat group developed non-alcoholic fatty liver disease; experienced changes in histones (the core set of proteins which DNA wrap around), and had altered metabolic profiles and circadian rhythms. Results also showed that the genes in the fetal liver, which are responsible for orchestrating circadian rhythms with appetite and food intake, are altered in offspring from the mothers on the high-fat diet. Specifically, one of these genes, called Npas2, is a key regulator of the circadian system and is itself regulated by changes in the fetal histone code. Scientists found that improving the diet, either for the pregnant or breastfeeding mother, or for the infant after birth, helps to partially restore the circadian machinery back to normal, possibly lessening the risk of childhood diseases related to obesity.

"We've recently published a number of studies in the FASEB Journal showing that what a mother eats affects the weight of her children for their entire lives," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Now, we know why, and what a wake-up call for pregnant women! The mother's diet during pregnancy affects their children's sleep machinery via genetic machinery that controls the sleep cycle. Children are literally forced to sleep in the proverbial bed their mothers have made."

Receive monthly highlights from the FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB). The journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information.

FASEB comprises 23 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB enhances the ability of scientists and engineers to improve—through their research—the health, well-being and productivity of all people. FASEB's mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Melissa Suter, Philip Bocock, Lori Showalter, Min Hu, Cynthia Shope, Robert McKnight, Kevin Grove, Robert Lane, and Kjersti Aagaard-Tillery
Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates

FASEB J. doi:10.1096/fj.10-172080 ; http://www.fasebj.org/content/early/2010/11/19/fj.10-172080.abstract

Cody Mooneyhan | EurekAlert!
Further information:
http://www.faseb.org

More articles from Life Sciences:

nachricht Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides
16.07.2018 | Tokyo Institute of Technology

nachricht The secret sulfate code that lets the bad Tau in
16.07.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Subaru Telescope helps pinpoint origin of ultra-high energy neutrino

16.07.2018 | Physics and Astronomy

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides

16.07.2018 | Life Sciences

New research calculates capacity of North American forests to sequester carbon

16.07.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>