The findings, to appear in the upcoming issue of the Proceedings of the National Academy of Sciences (PNAS), mark a first step toward the full-scale molecular-level simulation of biological cells.
Signaling processes in cells depend on a complex web of interactions whose macro-level behavior arises from micro-level dynamics of molecules. In mitogen-activated protein kinase (MAPK) cascades, a key pathway for signaling, such dynamics have been shown to generate rich phenomena such as ultrasensitivity and bistability that are critical to biological function. Conventional techniques for modeling MAPK, however, ignore such micro-scale dynamics to reduce computational time.
With their latest work, researchers at RIKEN and the FOM Institute for Atomic and Molecular Physics (AMOLF), Holland, have sidestepped this problem. The group applied a technique they developed, enhanced Green Function Reaction Dynamics (eGFRD), to simulate particle-level dynamics of the MAPK system, dramatically reducing computation time. Their results reveal that micro-level details of the interaction between enzyme and substrate molecules, overlooked in earlier models, can have a dramatic impact on the nature of response.
While challenging conventional theory, the findings also prelude an era of cellular simulations on a level of molecular detail never before possible. By exploiting the power of RIKEN's Next- Generation Supercomputer, currently under construction in Kobe, the new technique opens the door to the full-scale simulation of living cells, with key applications to cancer and stem cell research.
For more information, please contact:Dr. Koichi Takahashi
Saeko Okada | Research asia research news
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Life Sciences
17.08.2018 | Event News
17.08.2018 | Materials Sciences