Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Signals from the blood of the mother enhance the maturation of the brain

16.09.2008
Neuroscientists characterize the signalling chain

The maturation of the brain of unborn infants is given a gentle “prod” by its mother. A protein messenger from the mother’s blood is transferred to the embryo and stimulates the growth and wiring of the neurons in the brain.

Neuroscientists in Bochum (Prof. Petra Wahle, Developmental Neurobiology at the Ruhr University), Magdeburg (Dr. Peter Landgraf, Prof. Michael R. Kreutz) and in Münster (Prof. Hans-Christian Pape) performed a detailed investigation of this signal transduction pathway and identified those molecules in the brain of the embryo that interact with the maternal messenger. This achievement delivers an important step towards the comprehension of this signal transduction pathway. Their research work is published in the current volume of the Journal of Biological Chemistry.

The maternal immune system produces a signal molecule

In previous studies, the scientists had already managed to isolate the polypeptide messenger that plays a decisive role in the brain development of embryos and newborn infants, namely the “survival promoting peptide / Y P30.” Y-P30 enhances the survival of thalamic (diencephalic) neurons and promotes the neuritogenic activity of cerebellar and thalamic neurons. Prof. Wahle explained that it is “interesting to note that Y-P30 is not synthesized directly within the developing infant brain, but is produced by specific immune cells of the mother’s blood during pregnancy.

From there it passes the blood-placenta barrier and accumulates - inter alia - in neurons of the cerebral cortex of the embryo.” (Landgraf P, Sieg F, Wahle P, Meyer G, Kreutz MR, Pape HC (2005) “A maternal blood-borne factor promotes survival of the developing thalamus”. FASEB Journal 19:225-227.”) The scientists were able to provide evidence of the peptide in the brain of fetuses of mice and humans, and of postnatal rats.

Messengers need receptors to be effective

It was of particular interest to identify possible receptors for Y-P30 to enable investigation of the biological role of the messenger and to clarify its mechanisms of action. The research team has succeeded in identifying the molecules that interact with Y-P30, namely pleiotrophin, a protein within the extracellular space, and so-called syndecans, i.e. proteins on the cell surface. It was known that both binding partners could promote the growth of neurons. The scientists were now able to show the Y-P30 enhances the development of the pleiotrophin/syndecan signaling complex and stabilizes it.

The signaling activity within the neurons is increased and enhances the neuritogenic activity. Prof. Petra Wahle and Suvarna Wagh, PhD student in research training group 736, were able to demonstrate a direct action of the Y-P30 peptide on the growth of axons (neurites). The signal-receptor-complex comprised of Y-P30, pleiotrophin und syndecan thus appears to enhance the development of the axonal projection tracts and the wiring of the brain.

Prof. Dr. Petra Wahle | alfa
Further information:
http://www.rub.de

More articles from Life Sciences:

nachricht Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides
16.07.2018 | Tokyo Institute of Technology

nachricht The secret sulfate code that lets the bad Tau in
16.07.2018 | American Society for Biochemistry and Molecular Biology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Subaru Telescope helps pinpoint origin of ultra-high energy neutrino

16.07.2018 | Physics and Astronomy

Barium ruthenate: A high-yield, easy-to-handle perovskite catalyst for the oxidation of sulfides

16.07.2018 | Life Sciences

New research calculates capacity of North American forests to sequester carbon

16.07.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>