Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists find a new pharmacological target to modulate the effect of cannabinoids through their CB1 receptors

05.07.2012
A group or researchers from the Faculty of Biology of the University of Barcelona and the Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), a centre for biomedical network research on neurodegenerative diseases dependant on the Ministry of Economics and Competitiveness through the Carlos III Health Institute, has shown, in a research published in the Journal of Biological Chemistry, the expression of complexes known as heteromerswithin the cannabinoid receptors CB2 and CB1.
The results of this research may help in the better understanding of alterations where the CB1 receptor participates, such as in chronic pain, Parkinson's disease, cerebral trauma or brain tumours in which there may be a high inflammatory component.

Cannabis, commonly known as marihuana, is one of the most widely abused drugs among the European population. Its psychoactive substances act by interacting with proteins from the membrane of the cells which are their CB1 and CB2 receptors. In a natural way and independent of the marihuana, the cells themselves release compounds which are called endocannabinoids and they activate the CB1 and CB2 receptors to produce a physiological response.

The CB1 cannabinoid receptor is one of the most abundant receptors in the brain and it helps to regulate movement, as well as functioning as a therapeutic target for the treatment of pain, inflammation and Parkinson's disease, and it alleviates some side effects in cancer patients. Nevertheless, the CB2 cannabinoid receptors are far from being abundant in the brain and their function is not completely clear. This makes these receptors a subject of scientific interest, precisely because of the scarcity of information regarding their functioning.

The existence and function of the CB2 receptors in the neurons has always been controversial. This new research now offers two relevant conclusions: in the first place, the expression of CB2 as a protein in the neurons is confirmed and, in the second place, it is shown that the CB2 receptors may be a new pharmacological target for the modulation of the effect of cannabinoids through the CB1 receptor, forming CB1-CB2 heteromers which are expressed in the brain. The mission of CB2 in these heteromers is to repress the CB1 receptors, which could explain that during processes of inflammation, the CB2 receptors act as a brake on the CB1 receptors.

The research shows that it is necessary to take these heteromers into account for the effective design of medicines to counteract cannabinoid receptors, since these heteromers are the real targets and they show properties that are different from the individual receptors. This project has been carried out by the Molecular Neurobiology Research Group from the University of Barcelona, integrated in the campus of international excellence Barcelona Knowledg Campus (BKC), and the following lecturers worked on it: Dr. Peter McCormick, Dr. Enric I. Canela, Dr. Antoni Cortés, Dr. Carme Lluís, Dr. Josefa Mallol, Dr. Vicent Casadó, Dr. David Moreno-Delgado and Dr. Estefanía Moreno and the doctoral student Lucía Callén. Also participating in the project were Dr. José Luis Lanciego and Dr. Rafael Franco from the University of Navarra.

Parkinson's disease affects around 70,000 people in Spain

Neurodegenerative diseases (NDD) represent one of the most important health challenges in developed countries, because of their consequences for health and quality of life of those who suffer from them, as well as the socioeconomic burden that they represent. They are generally chronic, for the moment incurable, diseases and their common denominator is the death of neurons in different regions of the nervous system, which leads to the functional deterioration of the affected parts. In the case of Parkinson's disease, there are 70,000 people affected in Spain and the disease is characterized principally by the loss of neurons and the formation of Lewy bodies and Lewy neurites in the black substance and the consequent loss of striatal dopamine (DA). Nevertheless, it is currently well known that Parkinson's disease is a multisystemic neurodegenerative process, in which, as the neurodegenerative process evolves, numerous regions of the nervous system are affected and there exists a deficit in various systems of neurotransmission and neuromodulation.

The Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) is one of the reference centres in Spain for research on neurodegenerative diseases (NDD), such as Alzheimer’s, Parkinson’s, Huntington’s diseases and other ataxias and neuromuscular diseases. It was created in 2006 and its main objective is to promote basic biomedical, clinical and epidemiological research, as well as to ensure that the research carried out in laboratories can be put into practice and reach the patient (translational research). Legally it is organised as a public consortium where various institutions representing the Spanish General State Administration, the Spanish Autonomous Communities and other non-institutional organisations take part. It gathers a total of 58 Spanish research groups that share a common goal: the fight against neurodegeneration.
Bibliographische AngabenCannabinoid Receptors CB1 and CB2 Form Functional
Heteromers in Brain. Lucía Callén, Estefanía Moreno, Pedro Barroso-Chinea, David Moreno-Delgado, Antoni Cortés,

Josefa Mallol, Vicent Casadó, José Luis Lanciego, Rafael Franco, Carmen Lluis, Enric I. Canela, and Peter J. McCormick.

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 25, pp. 20851–20865, June 15, 2012

Hinweise an die RedaktionFurther information:

Dr. Peter McCormick
Dept. Bioquímica i Biologia Molecular (Biologia)
Facultat de Biologia - UNIVERSITAT DE BARCELONA
Tf 00 34 934039280
mailto: pmccormick@ub.edu

Rosa Martínez | alfa
Further information:
http://www.ub.edu

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>