Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Resveratrol Prevents Fat Accumulation in Livers of ‘Alcoholic’ Mice

15.10.2008
The accumulation of fat in the liver as a result of chronic alcohol consumption could be prevented by consuming resveratrol, according to a new study with mice. The research found that resveratrol reduced the amount of fat produced in the liver of mice fed alcohol and, at the same time, increased the rate at which fat within the liver is broken down.

Chronic alcohol consumption causes fat to accumulate and can lead to liver diseases, including cirrhosis and fibrosis of the liver. It can also result in liver failure. The study points to resveratrol as a possible treatment for alcoholic fatty liver disease, and as a way to prevent the disease in those who are at risk, but have not developed it.

Resveratrol is present in grapes, peanuts, berries and in red wine. Other research with mice has suggested resveratrol may have anti-cancer and anti-inflammatory properties. There is also evidence that it has cardiovascular benefits. However, these findings have not been extended to humans.

The study, "Resveratrol alleviates alcoholic fatty liver in mice," was carried out by Joanne M. Ajmo, Xiaomei Liang, Christopher Q. Rogers, Brandi Pennock and Min You, all of the University of South Florida Health Sciences Center, Tampa. The study appears in the American Journal of Physiology-Gastrointestinal and Liver Physiology, published by The American Physiological Society.

Activates cell signalers

The study builds on previous research, which suggests that alcohol inhibits two molecules that play a role in cell signaling and the breakdown of fats in the liver: AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1). When alcohol inactivates AMPK and SIRT1, it allows fat to accumulate. Resveratrol does the opposite -- activating AMPK and SIRT1, and helping to clear out fat.

In this study, the authors wanted to find out more about how this happens, at the molecular level. They divided mice into groups and fed all of them a low-fat diet. Some mice had resveratrol in their diet, some had resveratrol plus ethanol (alcohol), some had ethanol alone and some had neither ethanol nor resveratrol. The researchers used two different dose levels of resveratrol. At the end of the experiment, they examined the livers of the mice.

The researchers found, as they had expected, that resveratrol treatment increased the expression of SIRT1 and stimulated the activity of AMPK in the livers of mice fed alcohol. They further found that the increased expression of SIRT1 and AMPK led to:

• Reduction of sterol regulatory element binding protein (SREBP-1)

• Activation of peroxisome proliferator-activated receptor gamma co-activator alpha (PGC-1á)

• Elevation of circulating adiponectin, a hormone produced by fat cells, which helps control obesity

• Enhanced expression of adiponectin receptors in the liver, which increases the effectiveness of the circulating adiponectin

The findings suggest that resveratrol prevents alcoholic fatty liver by coordinating molecules that control fat metabolism. This prevents accumulation of fat in the mouse liver by both reducing the production of fat and burning off the fat that is there. Interestingly, the combination of alcohol with resveratrol appears to enhance the positive effects of resveratrol, said Dr. You, the study’s senior author.

"Our study suggests that resveratrol may serve as a promising agent for preventing or treating human alcoholic fatty liver disease," the authors concluded.

NOTE TO EDITORS: To interview Dr. You, please contact Christine Guilfoy at (301) 634-7253 or at cguilfoy@the-aps.org.

Funding: National Institute on Alcoholism and Alcohol Abuse.

Physiology is the study of how molecules, cells, tissues and organs function to create health or disease. The American Physiological Society (www.The-APS.org/press) has been an integral part of this discovery process since it was established in 1887.

Christine Guilfoy | Newswise Science News
Further information:
http://www.the-aps.org

More articles from Life Sciences:

nachricht Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>