Macrophages are real chatterboxes
Facebook, Instagram, Twitter – nowadays, good social networking and communication is more important than ever. The immune system also resembles a large social network, as shown by Felix Meissner and his team in the Experimental System Immunology Research Group at the Max Planck Institute of Biochemistry in Martinsried.
With the help of proteomics they deciphered the messages exchanged between immune cells responsible for protecting us against diseases. In doing so, they have discovered complex cellular communication structures and previously unknown connections between various cell types. Their findings were published in the journal Nature Immunology.
Social networks such as Facebook now connect people around the globe, for the exchange of countless messages and pieces of information every day. Some people prefer to use social networks passively, only reading messages, while others have a strong need to communicate with others and tend to send out a large volume of information. The cells of our immune system work in a similar manner.
When cells wish to communicate with each other, they emit messengers, unique signal molecules, which are detected by other cells via cell surface receptors. These messengers disseminate information throughout the body to control immune reactions against pathogens. Some cell types are more communicative than others. “Innate immune cells such as macrophages are real chatterboxes,” Meissner says.
Meissner and his colleagues searched for messengers and their receptors on cell surfaces using mass spectrometry-based proteomics. For their study, the scientists first sorted a total of 28 different immune cell types, including macrophages and lymphocytes, from the blood of healthy individuals by means of flow cytometry. Each cell type has a different function in the immune system and therefore, communicates differently. By sorting the cells, the researchers were able to study the unique communication behaviour of each cell type separately.
This large-scale analysis revealed the intricate communication networks between immune cells. “Every cell has a distinct character. We can determine who tells whom what story and also who is not listening,” Meissner reports. The researchers have identified previously unknown communication pathways between cell types. They also showed that the pattern of messengers and receptors on the surface of immune cells can change. “A fungal infection, for example, gives rise to a different network than, say, a bacterial infection,” Meissner explains.
In the future, the researchers want to investigate how cells communicate within tissues and how cellular communication behaviour changes during complex diseases. (Sas)
J.Rieckmann, R.Geiger, D.Hornburg, T.Wolf, Ksenya Kveler, D.Jarropssay, F.Sallusto, S.Shen-Orr, A.Lanzavecchia, M.Mann, & F.Meissner: Social network architecture of human immune cells unveiled by quantitative proteomics, Nature Immunology, March 2017
Dr. Felix Meissner
Department Experimental Systems Immunology
Max-Planck-Institut of Biochemistry
Am Klopferspitz 18
Dr. Christiane Menzfeld
Max Planck Institute of Biochemistry
Am Klopferspitz 18
Dr. Christiane Menzfeld | Max-Planck-Institut für Biochemie
A new molecular player involved in T cell activation
07.12.2018 | Tokyo Institute of Technology
News About a Plant Hormone
07.12.2018 | Julius-Maximilians-Universität Würzburg
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
06.12.2018 | Event News
03.12.2018 | Event News
28.11.2018 | Event News
07.12.2018 | Life Sciences
07.12.2018 | Materials Sciences
07.12.2018 | Physics and Astronomy