Researchers identify potential patient safety risks among methadone maintenance treatment patients

Improved communication and coordination among substance use treatment and medical providers could mitigate and manage the potential adverse effects of methadone and interacting medications. The BMC study appears in the July issue of Journal of General Internal Medicine.

MMT is a chronic therapy for opioid dependence, a chronic relapsing disease that often requires lifelong treatment. MMT typically is provided separately from medical care. Ideally, when patients in MMT engage in outpatient or inpatient medical care, treating physicians are aware of MMT and document both methadone on the medication list and opioid dependence on the medical problem list. When this is not done, there is a chance for medication-methadone interactions, which could potentially contribute to clinically significant adverse events, including cardiac arrhythmias, overdoses and decreased cognitive function.

BMC researchers aimed to identify potential patient safety risks among MMT patients engaged in medical care by evaluating the frequency that opioid dependence and MMT documentation were missing in medical records and characterizing potential medication-methadone interactions.

The researchers found documentation of opioid dependence diagnosis was missing from the medical record in 30 percent of subjects; documentation of MMT was missing from either the last discharge summary or last primary care note in 11 percent of subjects; among subjects seen by a primary care doctor, documentation of MMT was missing in 7 percent; among subjects discharged from the inpatient hospital, documentation of MMT was missing in 10 percent. Sixty-nine percent of the study subjects were taking at least one medication that potentially interacted with methadone and 19 percent were taking three or more potentially interacting medications.

“Among patients receiving MMT and medical care at different sites, documentation of opioid dependence and MMT in the medical record occurs for the majority, but is missing in a substantial number of patients,” said lead author Alexander Walley, MD, MSc, general internist in the Clinical Addiction Research and Education Unit at BMC and assistant professor of medicine at Boston University School of Medicine. “Most of these patients are taking prescribed medications that potentially interact with methadone. This study demonstrates opportunities to improve communication, care coordination, and patient safety among patients receiving medical and substance use treatment.”

This study was supported by the National Institute of Drug Abuse. The Institute had no role in the design and conduct of the study, the collection, management, analysis and interpretation of the data, or the preparation, review and approval of the manuscript.