N. gonorrhoeae is a pathogenic bacterium that readily develops resistance to antibiotics such as sulfanilamides, penicillins, tetracyclines and fluoroquinolones. It has recently been reported that N. gonorrhoeae is becoming resistant to cephalosporins, which are the only treatment option recommended by the Centers for Disease Control and Prevention (CDC). Today, new therapeutic methods other than antibiotics are in great need to treat these infections.
According to the BUSM researchers, understanding the process of how N. gonorrhoeae causes disease in both men and women is essential for the design of new targets to block the infection. "The first step in the disease gonorrhea is the colonization of bacteria on human mucosal surfaces, such as the vaginal and penile mucosa," explained senior author Caroline Genco, PhD, professor of medicine and microbiology and director of research in infectious diseases at BUSM.
In this study, Genco and her colleagues identified a novel pathway that is critical for colonization of this bacterium on host mucosal surface. The key of this pathway is a single protein, designated as Fur, the ferric uptake regulatory protein, which controls the expression of hundreds of N. gonorrhoeae genes by either increasing or decreasing the expression of these genes.
The study found that genes whose expression is increased by Fur may play a critical role in the prevention of disease development by triggering the host immune system to recognize and clear the bacterium.
"These pivotal studies provide new candidates that can be targeted for therapeutic intervention in this common sexually transmitted disease," she added.
Gina DiGravio | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences