The team, whose principal investigators include Gregory Frolenkov of the UK Department of Physiology, developed “hopping probe ion conductance microscopy,” in which a nanoscale probe “hops” over the surface of a cell in an action similar to a sewing machine needle. They published their development in this week’s edition of Nature Methods.
The technique permitted the researchers to visualize the surface of a complex living cell at a nanoscale resolution, which was previously possible only in dead cells using electron microscopy.
“Now we can see nanostructures such as individual protein or protein complexes in a living cell and probe their function. Many diseases affect the cell surface.
Therefore, we expect that our technique, together with emerging high-resolution imaging techniques looking inside the cell, will clarify the mechanisms of a number of diseases, the same way as a regular optical microscope revolutionized medicine centuries ago,” Frolenkov said.
The other co-principal investigators on the project are Yuri E. Korchev of the Imperial College London Division of Medicine in London, United Kingdom, and David Klenerman of Cambridge University’s Department of Chemistry in Cambridge, United Kingdom. Also participating in the research was Ruben Stepanyan of the UK Department of Physiology, part of the UK College of Medicine.
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A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
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