Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find that inhibiting microRNAs may help prevent degenerative eye disorders

07.06.2011
Blocking two tiny molecules of RNA – a chemical cousin of DNA – appears to suppress the abnormal growth of blood vessels that occurs in degenerative eye disorders, UT Southwestern Medical Center researchers have found.

Their findings, available in the Proceedings of the National Academy of Sciences, suggest a potential strategy to treat age-related macular degeneration (AMD), a vascular eye disorder that affects nearly 2 million Americans and is a leading cause of blindness among older people.

"MicroRNAs can affect multiple pathways involved in age-related macular degeneration," said Dr. Shusheng Wang, assistant professor of ophthalmology and pharmacology and co-senior author of the study. "Therapeutic manipulation of microRNAs 23 and 27 may give us a way to treat choroidal neovascularization in patients with degenerative retinal diseases."

In the study, researchers found that silencing the microRNA cluster members miR-23 and miR-27 hindered the excessive formation of blood vessels in the back of the eye, known as choroidal neovascularization. When these blood vessels hemorrhage and leak, it creates a sudden deterioration of central vision.

MicroRNAs are tiny pieces of genetic material that can target multiple components of signaling pathways. By interacting with other protein-making molecules in cells, they help fine-tune the expression of networks of genes and control cell function.

But microRNAs also can contribute to the excessive blood vessel formation that is responsible for vascular disorders, the current UT Southwestern study shows. That's because they stimulate the growth of new blood vessels from pre-existing vessels, a process called angiogenesis, which is an important natural process in the body used for healing and reproduction.

The body usually controls angiogenesis through a precise balance of growth and inhibitory factors in healthy tissues, Dr. Wang said. When the process becomes imbalanced, however, increased angiogenesis can lead to a variety of debilitating conditions.

Previous treatments for degenerative eye disorders have focused on inhibiting vascular endothelial growth factor (VEGF), a secreted protein that stimulates blood vessel formation. VEGF has been known to be a contributing factor in vascular disease in the retina of the eye.

Anti-VEGF drugs, which are injected into the eyeball, have been used to give patients some improvement in vision. These drugs, however, have limited effectiveness in treating some forms of neovascular AMD, and also have potential side effects.

Dr. Wang said further research may show that other microRNAs might also be involved, and that targeting multiple pathways may provide benefits in the treatment of these diseases.

"We want to see if a combination of microRNAs and angiogenetic drugs have a synergetic effect on the progression of macular degeneration," Dr. Wang said.

Dr. Eric Olson, chairman of molecular biology, was the study's other co-senior author. Other UT Southwestern researchers involved were Dr. Rafael Ufret-Vincenty, assistant professor of ophthalmology, Dr. Qinbo Zhou, postdoctoral fellow and lead author; Rachel Gallagher, research technician; and Dr. Xinyu Li, a visiting professor.

The study was supported by a startup fund from the Department of Ophthalmology and grants from the National Institutes of Health and from the Research to Prevent Blindness Foundation.

Visit http://www.utsouthwestern.org/ophth to learn more about UT Southwestern's clinical services in ophthalmology.

This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html

To automatically receive news releases from UT Southwestern via email, subscribe at www.utsouthwestern.edu/receivenews

Robin Russell | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>