The most recent findings are discussed in detail in his team’s research paper “Physicochemical characterization, and relaxometry studies of micro-graphite oxide, graphene nanoplatelets, and nanoribbons,” published in the June 7 edition of the journal PLoS ONE.
The MRI, the technology for which was invented at Stony Brook University by Professor Paul Lauterbur, is one of the most powerful and central techniques in diagnostic medicine and biomedical research used primarily to render anatomical details for improved diagnosis of many pathologies and diseases. Currently, most MRI procedures use gadolinium-based contrast agents to improve the visibility and definition of disease detection. However, recent studies have shown harmful side effects, such as nephrogenic systemic fibrosis, stemming from the use of this contrast agent in some patients, forcing the Food and Drug Administration (FDA) to place restrictions on the clinical use of gadolinium. Further, most MRI contrast agents are not suitable for extended-residence-intravascular (blood pool), or tissue (organ)-specific imaging, and do not allow molecular imaging.
To address the need for an MRI contrast agent that demonstrates greater effectiveness and lower toxicity, Dr. Sitharaman developed a novel high-performance graphene-based contrast agent that may replace the gadolinium-based agent which is widely used by physicians today. “A graphene-based contrast agent can allow the same clinical MRI performance at substantially lower dosages,” said Dr. Sitharaman. The project is a Wallace H. Coulter Foundation Translational Research Award winner and the recipient of a two-year translational grant to study preclinical safety and efficacy.
“The technology will lower health care costs by reducing the cost per dose as well as the number of doses required,” noted Dr. Sitharaman. “Further, since this new MRI contrast agent will substantially improve disease detection by increasing sensitivity and diagnostic confidence, it will enable earlier treatment for many diseases, which is less expensive, and of course more effective for diseases such as cancer.”
The new graphene-based imaging contrast agent is also the focus of Dr. Sitharaman’s start-up company, Theragnostic Technologies, Inc., which was incorporated in early 2012. The ongoing development of this technology is supported by industry expert and business advisor, Shahram Hejazi, and clinical experts Kenneth Shroyer, MD, PhD, Professor and Chair, Department of Pathology, Stony Brook University, and William Moore, MD, Chief of Thoracic Imaging, and Assistant Professor, Department of Radiology, Stony Brook University. Co-authors of the article include Department of Biomedical Engineering research assistants Bhavna Paratala, Barry Jacobson and Shruti Kanakia; and Leonard Deepak Francis from the International Iberian Nanotechnology Laboratory in Portugal.
Dr. Sitharaman’s research team focuses their interests at the interface of bionanotechnology, regenerative and molecular medicine. They seek to “synergize” the advancements in each of these fields to develop a dynamic research program that tackles problems related to the diagnosis and treatment of disease and tissue regeneration. Dr. Sitharaman received his BS with Honors from the Indian Institute of Technology and his PhD from Rice University, where he also completed his postdoctoral work as a J. Evans Attwell-Welch Postdoctoral Fellowship recipient.
Lauren Sheprow | Newswise Science News
A Varied Menu
25.03.2019 | Albert-Ludwigs-Universität Freiburg im Breisgau
Key evidence associating hydrophobicity with effective acid catalysis
25.03.2019 | Tokyo Metropolitan University
DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.
The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...
Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.
The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...
Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.
Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...
The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.
A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...
Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
11.03.2019 | Event News
01.03.2019 | Event News
28.02.2019 | Event News
25.03.2019 | Trade Fair News
25.03.2019 | Life Sciences
25.03.2019 | Information Technology