Each year, nearly 500,000 Americans are admitted to hospitals for staph infections. Research shows that more than 50 percent of those are from methicillin-resistant S. aureus, or MRSA, which is resistant to current antibiotics.
Boise State biology scientists created a vaccine that uses a cholera toxin molecule called A2/B chimera, which also contains an iron-regulated surface determinant from S. aureus, that was given to mice through the nose. The researchers believed that these stable chimeric molecules with unique binding properties would provide immunity to staph infections. The results supported this theory and showed that the new vaccine could induce significant immunity to staph in mice when delivered through the nose.
The results appear online in the journal Clinical and Vaccine Immunology.
“We knew that a successful vaccine against staph would have to contain a combination of antigens,” study co-author Juliette Tinker, assistant professor of biological sciences at Boise State. “Staph is a very complex bacteria that has a lot of proteins on the surface that change frequently, so we picked one that seemed to be present in many of the strains of staph. We knew only incorporating one or two proteins into a vaccine wasn’t enough, we needed many.”
Tinker and her research team studied the immune response in 24 mice that were given the vaccine they created and measured how many antibodies the mice produced against staph over 45 days. The results showed the mice had a significant number of antibodies against staph, although a booster dose was needed after the 10th day.
Matt Pene | Newswise Science News
A landscape of mammalian development
21.02.2019 | Max-Planck-Institut für molekulare Genetik
Atopic dermatitis: elevated salt concentrations in affected skin
21.02.2019 | Technische Universität München
Up to now, OLEDs have been used exclusively as a novel lighting technology for use in luminaires and lamps. However, flexible organic technology can offer much more: as an active lighting surface, it can be combined with a wide variety of materials, not just to modify but to revolutionize the functionality and design of countless existing products. To exemplify this, the Fraunhofer FEP together with the company EMDE development of light GmbH will be presenting hybrid flexible OLEDs integrated into textile designs within the EU-funded project PI-SCALE for the first time at LOPEC (March 19-21, 2019 in Munich, Germany) as examples of some of the many possible applications.
The Fraunhofer FEP, a provider of research and development services in the field of organic electronics, has long been involved in the development of...
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
21.02.2019 | Life Sciences
21.02.2019 | Earth Sciences
21.02.2019 | Life Sciences