New research published in the online open access journal BMC Genomics is the first to show that this chemical can affect the breasts' genomic profile.
Jose Russo and coworkers from the Fox Chase Cancer Center in Philadelphia, along with colleagues from the University of Alabama in Birmingham, US, fed lactating rats with butyl benzyl phthalate (BBP), which their offspring then absorbed via breast milk. The offspring ingested levels of chemical estimated to be nearly equivalent to the Environmental Protection Agency's safe dose limit of BBP for humans.
The researchers found that BBP had a transitory effect on certain characteristics of the female offspring of the rats, such as the ratio of uterine weight to body weight and the genetic profile of the mammary gland. Dr Russo stated: "We are the first to report that neonatal/prepubertal exposure to BBP induced modifications in the gene expression of the mammary tissue."
Although these effects wore off once exposure to BBP was removed, the subtle changes in the mammary gland may have an effect later in life.
BBP is widely used as a plasticizer, an additive used to soften polymers, and is found in household fittings such as pipes, vinyl floor tiles and carpet backing. This type of chemical is known to be an endocrine disruptor, which mimics the effect of hormones. Endocrine disruptors are known to damage wildlife and they have also been implicated in reduced sperm counts and neurological problems in humans.
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Straight to the heart
24.06.2019 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
From June 25th to 27th 2019, the Fraunhofer Institute for Digital Media Technology IDMT in Ilmenau (Germany) will be presenting a new solution for acoustic quality inspection allowing contact-free, non-destructive testing of manufactured parts and components. The method which has reached Technology Readiness Level 6 already, is currently being successfully tested in practical use together with a number of industrial partners.
Reducing machine downtime, manufacturing defects, and excessive scrap
The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.
Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...
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Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
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