Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Stem cells train heart following heart attack

27.11.2007
Following a heart attack, part of the heart tissue dies. It is still not possible to restore the scar tissue arising as a result of this. The majority of stem cell researchers attempt to make new heart muscle cells from stem cells.

Liesbeth Winter of the Leiden University Medical Center, however, was able to prove the concept of using the embryonic potential of adult human cells to train the heart: this cell therapy ensured that less tissue died and that the remaining heart cells functioned better.

The PhD student used the 'Epicardium Derived Cell' or EPDC. This cell plays a crucial role during embryonic heart development: the embryonic EPDCs provide cells for the connective tissue skeleton of the heart and for the walls of the coronary arteries. EPDCs also play an important role in the formation of a thick, compact heart muscle wall. Without EPDCs, the heart muscle would remain very thin and the embryo would die.

Human cells stimulate mouse cells

... more about:
»EPDC »Heart »following

Winter used adult human EPDCs that she extracted from the atrium of the heart. She transplanted these cells to a mouse heart that had suffered an infarction. The mice receiving these cells retained a better heart function than mice without these cells, both in the short term and in the longer term of several weeks. The human cells also ensured that less mouse cells died off. Two weeks following cell transplantation, the treated hearts contained more blood vessels, the heart muscle cells exhibited an increased activity of DNA damage repair, and the wall was thicker where the infarct had occurred. These results suggest that EPDCs have an almost instant stimulating effect on the surrounding heart tissue following transplantation.

The Dutch Programme on Tissue Engineering has been running since 2004. Prior to this, NWO, Technology Foundation STW, and ZonMw had made 3 millions euros available for a pilot programme in this area. The DPTE programme has been funded to the tune of M€ 50. Half of the funding came from a subsidy of M€ 25 obtained from the Dutch government's Bsik programme (Grants for Investments in Knowledge Infrastructure).

Sonja Knols | alfa
Further information:
http://www.nwo.nl/nwohome.nsf/pages/NWOA_78AGN2_Eng

Further reports about: EPDC Heart following

More articles from Life Sciences:

nachricht Colorectal cancer: Increased life expectancy thanks to individualised therapies
20.02.2020 | Christian-Albrechts-Universität zu Kiel

nachricht Sweet beaks: What Galapagos finches and marine bacteria have in common
20.02.2020 | Max-Planck-Institut für Marine Mikrobiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Active droplets

21.02.2020 | Medical Engineering

Finding new clues to brain cancer treatment

21.02.2020 | Health and Medicine

Beyond the brim, Sombrero Galaxy's halo suggests turbulent past

21.02.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>