Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Shinya Yamanaka reprograms human adult cells

21.11.2007
Breakthrough accelerates new avenues of stem cell research

Acclaimed stem cell researcher Shinya Yamanaka, MD, PhD, has reported that he and his Kyoto University colleagues have successfully reprogrammed human adult cells to function like pluripotent embryonic stem (ES) cells. Because it circumvents much of the controversy and restrictions regarding generation of ES cells from human embryos, this breakthrough, reported in the journal Cell, should accelerate the pace of stem cell research.

Last year, Yamanaka, who is also a senior investigator at the Gladstone Institute of Cardiovascular Disease (GICD), reported that he and his Kyoto colleagues had reprogrammed mouse skin cells into pluripotent stem cells, laying the foundation to apply this methodology in human cells.

In this earlier work, published in Cell, Yamanaka and his colleagues identified four genetic factors that resulted in the reprogramming of adult mouse cells into induced pluripotent stem (iPS) cells capable of developing into any kind of cell. This summer, he reported in Nature that these iPS cells could even form a new mouse, making them functionally the same as ES cells. According to the new research, those same genetic factors used with human adult cells resulted in iPS cells which are nearly indistinguishable from human ES cells.

... more about:
»Adult »Stem »Yamanaka »pluripotent »stem cells

“The rapid application of this approach to human cells has dramatically changed the landscape of stem cell science,” said GICD Director Deepak Srivastava, MD. “Dr. Yamanaka’s work is monumental in its importance to the field of stem cell science and its potential impact on our ability to accelerate the benefits of this technology to the bedside. Not only does this discovery enable more research, it offers a new pathway to apply the benefits of stem cells to human disease.”

“Dr. Yamanaka and his group have made yet another extremely important contribution to the stem cell field,” said Richard Murphy, interim president of the California Institute for Regenerative Medicine (CIRM). “Their results open the door to generating alternative sources of pluripotent cells from patients, which is a major step forward. However, much work still needs to be done to fully characterize and understand the capacity of these induced pluripotent cells to study and to treat human diseases.”

While Yamanaka’s work would seem to eliminate the need for controversial research on human embryos, both he and Srivastava emphasized that research must continue. “We are still a long way from finding cures or therapies from stem cells and we don’t know what processes will be effective,” Yamanaka said.

CIRM’s Murphy added, “Dr. Yamanaka’s work, which uses viral vectors to introduce into cells pluripotency-associated genes, further emphasizes the critical need we have to continue working with naturally occurring human embryonic stem cells, which remain the gold standard against which all alternative sources of human pluripotent stem cells must be tested.”

According to Yamanaka, the next steps will be to understand how these cells can be differentiated into other types of cells and ultimately how they can be used to study disease models and as potential therapies. “We are now finally in a position to make patient-specific stem cells for therapies without fear of immune-rejection and to make disease-specific stem cells that will reveal the underlying cause of many human diseases” he said.

Valerie Tucker | EurekAlert!
Further information:
http://www.gladstone.ucsf.edu

Further reports about: Adult Stem Yamanaka pluripotent stem cells

More articles from Life Sciences:

nachricht Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland

nachricht Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>