The idea that MMTV is involved in human breast cancer has been around for over 50 years. In the 1990s, researchers detected MMTV in human breast tumors, but not in healthy breast tissue. The link between MMTV and human breast cancer was contentious though, as some scientists believed the presence of MMTV in tumors was caused by contamination rather than infection.
However, two years ago, researchers from the University of Veterinary Medicine, Austrianova Biotechnology and the Christian-Doppler Laboratory for Gene Therapeutic Vector Development, all based in Vienna, Austria, showed that MMTV does actually infect human cells.
Now, they have added to these findings with this latest study, which shows that MMTV can replicate in cultured human breast cells. The new virus particles produced by the infected cells enabled the virus to spread rapidly, leading to the infection of every cell in culture.
"It has recently been shown convincingly that MMTV can infect human cells. Often, however, viruses infect cells but cannot replicate further. If they can replicate, the chances that they cause disease may be increased," says Dr Stanislav Indik from the University of Veterinary Medicine, Vienna and one of the study's authors.
There are a number of questions still to be answered before a concrete role of MMTV in human breast cancer is established, including whether MMTV can infect primary cells - those taken directly from the body, not from a cultured cell line. Also, researchers plan to investigate how the virus spreads from mice to humans, and to examine if one of the possible outcomes of human MMTV infection is breast cancer.
MMTV is a retrovirus, the same kind of virus as HIV. If MMTV is eventually found to play a role in human breast cancer, current treatments for HIV may also be effective against MMTV.
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences