A molecule that protects from neuronal disorders

Many neuronal disorders, including epilepsy, schizophrenia and lissencephaly – a form of mental retardation -, result from abnormal migration of nerve cells during the development of the brain.

Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy, have now discovered that a protein that helps organising the cells’ skeleton is crucial for preventing such defects. In the current issue of Genes & Development they report that mice lacking the protein show symptoms of lissencephaly brought about by faulty development of the cerebral cortex, the brain’s surface layer.

The cerebral cortex is a complex structure with many important functions and a very unique architecture consisting of different cell types arranged in a specific order of layers. During embryonic development the cortical layers are generated by neuronal progenitor cells that migrate long distances before they settle down in a given layer. The spatial organisation in cell layers is essential to cortical functions. When the layer architecture is disturbed, like in the case of lissencephaly where entire layers are missing, the consequences are mental retardation, muscle spasms and seizures. The new study by a team of EMBL researchers reveals that a molecule called n-cofilin can play a key role in the disease.

“We genetically engineered mice that lack n-cofilin and they show the same anatomical defects and symptoms as patients suffering from lissencephaly,” says Walter Witke, whose team carried out the research. “Their brains miss several cortical layers because neurons do not migrate normally during development.”

The ability of neurons to migrate is largely brought about by the dynamic properties of their skeleton. The skeleton of a cell consists of constantly growing and shrinking filaments that function like strings and struts to give the cell shape and stability. N-cofilin interacts with one kind of filaments, called actin filaments, and helps to disassemble them into their individual building blocks. Interfering with this filament remodeling impairs the cell’s ability to move and thus blocks migration of neurons during cortical development.

N-cofilin also controls the fate of neural stem cells, which are involved in development of the cortex. In its absence more stem cells stop to self-renew and instead start differentiating. This imbalance depletes the pool of neuronal progenitors so that fewer cells can be made to build a complete and functional cortex. The study provides the first proof that proteins affecting actin filament dynamics are involved in neuronal migration disorders.

“This might have implications for humans, too,” says Gian Carlo Bellenchi from Witke’s lab. “Like many other cytoskeletal proteins n-cofilin is conserved between mice and humans and it is likely to play a similar role in the development of the human cortex.”

This makes the gene encoding n-cofilin an interesting candidate that might be mutated in neuronal disorders such as lissencephaly and other forms of mental retardation.

“The mouse model is a powerful tool to further investigate the roles n-cofilin and the actin cytoskeleton play in stem cell physiology and cell migration. Our studies also identified n-cofilin as a potential target molecule that might allow to interfere with stem cell function in diseases where stem cell division has derailed,” concludes Christine Gurniak from Witke’s group.

Published online in Genes & Development on 15 September 2007.

Anna-Lynn Wegener
Press Officer
EMBL
Meyerhofstrasse 1
D-69117 Heidelberg
tel. +49-6221-3878452
fax +49-6221-387525
wegener@embl.de

Media Contact

Anna-Lynn Wegener EMBL

All latest news from the category: Life Sciences and Chemistry

Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to home

Comments (0)

Write a comment

Newest articles

Results for control of pollutants in water

Brazilian scientists tested a simple and sustainable method for monitoring and degrading a mixture of polycyclic aromatic hydrocarbons, compounds present in fossil fuels and industrial waste. An article published in the journal Catalysis…

A tandem approach for better solar cells

Perovskite-based solar cells were first proved in 2009 to have excellent light-absorbing properties of methylammonium lead bromide and methylammonium lead iodide, collectively referred to as lead halide perovskites or, more…

The behavior of ant queens is shaped by their social environment

Specialization of ant queens as mere egg-layers is reversible / Queen behavioral specialization is initiated and maintained by the presence of workers. The queens in colonies of social insects, such…

Partners & Sponsors