Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Discovery of HIV’s strategy for multiplying in white blood cells

12.09.2007
The AIDS virus (HIV) attacks immune system cells and once inside them it multiplies. In some of these immune cells, viral stocks are not very accessible to antiviral therapy.

CNRS, Institut Curie and Institut Pasteur researchers investigating how HIV avoids being destroyed by immune cells have discovered that HIV alters the pH of the cellular compartments where it accumulates, thus stopping the activation of the very enzymes that would normally degrade it. This work was published in the 16 August 2007 issue of Cell Host and Microbe.

When viruses or infectious bacteria enter our body, the immune system is triggered to eliminate them, through a process involving various types of white blood cells. Some viruses target the immune system. For example, HIV (human immunodeficiency virus) attacks two sorts of white blood cells: macrophages, which play an early role in immune defense by phagocytosing and then digesting the invader, and certain lymphocytes (CD4 T lymphocytes), which come into play later in the immune response. HIV accumulates in the infected macrophages, which are veritable viral reservoirs pretty much inaccessible to antiviral treatments. Multiplication of HIV destroys the CD4 T lymphocytes.

At the Institut Curie, Philippe Benaroch, CNRS Director of Research, and his Intracellular Transport and Immunity group in the Inserm laboratory (1), have been studying the immune system and how it breaks down. They have investigated the proliferation of HIV in macrophages, in collaboration with their colleagues in the Virus and Immunity Laboratory of the Institut Pasteur associated with the CNRS(2). They have shown that the viral particles accumulate in certain compartments of the infected macrophages. Now, these compartments normally have an acid pH at which HIV shouldn’t survive. But pH measurements have revealed that HIV manages to impair the acidification of these compartments and so create an environment where it can survive and multiply. In these compartments, the enzymes that degrade viruses need an acid pH to work effectively, and so are put out of action by the change in pH produced by HIV. By controlling its environment, HIV can multiply within the infected macrophages, where compartments not containing viral proteins or particles seem to function normally.

... more about:
»Cells »HIV »accumulate »compartments »infected »macrophages

This study sheds new light on how HIV remains infectious for long periods of time in infected patients, and points the way to the identification of new therapeutic targets for the elimination of viral stocks in macrophages.

Catherine Goupillon | alfa
Further information:
http://www.cellhostandmicrobe.com/

Further reports about: Cells HIV accumulate compartments infected macrophages

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>