The researchers of the IRIBHM have prooved, by the use of these genetically-modified mice, that those abnormalities of B lymphocytes development and function are the result of an overexpression of molecule furthering apoptosis. The consequence of this overexpression is thus a decreased survival of the B lymphocytes and defect in antibody production in response to certain agents.
The IRIBHM’s team has also suggested a mechanism by which Inositol 1,3,4,5 tetrakisphosphate, the product generated by Itpkb, plays a significant role in the development and function of B lymphocytes : it controls the subcellular localization of the Rasa 3 enzyme, one of its intracellular receptors. Indeed, production of inositol 1,3,4,5-tetrakisphosphate in the cell results in the dissociation of the Rasa 3 receptor from the cell membrane and its inactivation.
This work follows other research still under way at the IRIBHM and focused on the unexpected but significant role of the Itpkb enzyme in T lymphocytes development. Considering the localization of the Itpkb gene in a region of the chromosom 1 known in man and mouse to contain several predisposition genes to autoimmune disease and considering this gene’s function in T and B lymphocytes development, the researchers of the IRIBHM investigate the hypothesis according to which alterations in this Itpkb gene could eventuallly favour the appearance of autoimmune disease (Disseminated Lupus Erythmatosus, type 1 diabetes,…).
This research, recently published in PNAS, has been done in collaboration with teams from the ULB (IRIBHM, IBMM), the Université de Genève, Harvard University and Bristol University.
Nancy Dath | alfa
Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow
16.07.2019 | Rudolf-Virchow-Zentrum für Experimentelle Biomedizin der Universität Würzburg
A human liver cell atlas
15.07.2019 | Max Planck Institute of Immunobiology and Epigenetics
Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal “Haematologica”.
Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The bone marrow produces all types of blood cells: red...
For some phenomena in quantum many-body physics several competing theories exist. But which of them describes a quantum phenomenon best? A team of researchers from the Technical University of Munich (TUM) and Harvard University in the United States has now successfully deployed artificial neural networks for image analysis of quantum systems.
Is that a dog or a cat? Such a classification is a prime example of machine learning: artificial neural networks can be trained to analyze images by looking...
An international research group led by scientists from the University of Bayreuth has produced a previously unknown material: Rhenium nitride pernitride. Thanks to combining properties that were previously considered incompatible, it looks set to become highly attractive for technological applications. Indeed, it is a super-hard metallic conductor that can withstand extremely high pressures like a diamond. A process now developed in Bayreuth opens up the possibility of producing rhenium nitride pernitride and other technologically interesting materials in sufficiently large quantity for their properties characterisation. The new findings are presented in "Nature Communications".
The possibility of finding a compound that was metallically conductive, super-hard, and ultra-incompressible was long considered unlikely in science. It was...
An interdisciplinary research team at the Technical University of Munich (TUM) has built platinum nanoparticles for catalysis in fuel cells: The new size-optimized catalysts are twice as good as the best process commercially available today.
Fuel cells may well replace batteries as the power source for electric cars. They consume hydrogen, a gas which could be produced for example using surplus...
The fly agaric with its red hat is perhaps the most evocative of the diverse and variously colored mushroom species. Hitherto, the purpose of these colors was...
24.06.2019 | Event News
29.04.2019 | Event News
17.04.2019 | Event News
16.07.2019 | Physics and Astronomy
16.07.2019 | Power and Electrical Engineering
16.07.2019 | Information Technology