The researchers of the IRIBHM have prooved, by the use of these genetically-modified mice, that those abnormalities of B lymphocytes development and function are the result of an overexpression of molecule furthering apoptosis. The consequence of this overexpression is thus a decreased survival of the B lymphocytes and defect in antibody production in response to certain agents.
The IRIBHM’s team has also suggested a mechanism by which Inositol 1,3,4,5 tetrakisphosphate, the product generated by Itpkb, plays a significant role in the development and function of B lymphocytes : it controls the subcellular localization of the Rasa 3 enzyme, one of its intracellular receptors. Indeed, production of inositol 1,3,4,5-tetrakisphosphate in the cell results in the dissociation of the Rasa 3 receptor from the cell membrane and its inactivation.
This work follows other research still under way at the IRIBHM and focused on the unexpected but significant role of the Itpkb enzyme in T lymphocytes development. Considering the localization of the Itpkb gene in a region of the chromosom 1 known in man and mouse to contain several predisposition genes to autoimmune disease and considering this gene’s function in T and B lymphocytes development, the researchers of the IRIBHM investigate the hypothesis according to which alterations in this Itpkb gene could eventuallly favour the appearance of autoimmune disease (Disseminated Lupus Erythmatosus, type 1 diabetes,…).
This research, recently published in PNAS, has been done in collaboration with teams from the ULB (IRIBHM, IBMM), the Université de Genève, Harvard University and Bristol University.
Nancy Dath | alfa
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Russian researchers together with their French colleagues discovered that a genuine feature of superconductors -- quantum Abrikosov vortices of supercurrent -- can also exist in an ordinary nonsuperconducting metal put into contact with a superconductor. The observation of these vortices provides direct evidence of induced quantum coherence. The pioneering experimental observation was supported by a first-ever numerical model that describes the induced vortices in finer detail.
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Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
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The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
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