Molecular interactions that regulate the circadian clock happen within milliseconds, yet the body clock resets about every 24 hours. What, then, stretches the expression of the clock over such a relatively long period?
Cornell researchers have contributed to the answer, thanks to new mathematical models recently published.
In the August online edition of Public Library of Science (PLOS) Computational Biology, Cornell biomolecular engineer Kelvin Lee, in collaboration with graduate student Robert S. Kuczenski, Kevin C. Hong '05 and Jordi Garcia-Ojalvo of Universitat Politecnica de Catalunya, Spain, hypothesize that the accepted model of circadian rhythmicity may be missing a key link, based on a mathematical model of what happens during the sleeping/waking cycle in fruit flies.
"We didn't discover any new proteins or genes," Lee said. "We took all the existing knowledge, and we tried to organize it."
Using mathematical models initially created by Hong, who has since graduated, the team set out to map the molecular interactions of proteins called period and timeless -- widely known to be related to the circadian clock.
The group hypothesized that an extra, unknown protein would need to be inserted into the cycle with period and timeless, a molecule that Kuczenski named the focus-binding mediator, in order for the cycle to stretch to 24 hours.
Lee said many scientists are interested in studying the circadian clock, and not just to understand such concepts as jet lag -- fatigue induced by traveling across time zones. Understanding the body's biological cycle might, for example, lead to better timing of delivering chemotherapy, when the body would be most receptive, Lee said.
Press Relations Office | EurekAlert!
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences