However, there is a need for new pharmaceutical alternatives, since not all patients respond to the existing medicines. Thanks to the research partly carried out at the European Synchrotron Radiation Facility (ESRF), it is now possible to tailor new molecules that can block the LTC4 synthase. “I believe this breakthrough will speed up drug discovery against this disease”, explains Andrew McCarthy, one of the researchers in the team.
Scientists from the Karolinska Institute and the University of Stockholm in Sweden, together with colleagues from the European Molecular Laboratory in France have solved the three dimensional structure of the LTC4 synthase at 2.0 Ångstrom resolution . The protein has three identical subunits, each consisting of four helical structures that span the membrane. The structure finally allows the exact position and characteristics of the active sites, where activating or blocking molecules can bind, to be identified.
The study of this protein at the ESRF proved a challenge for the team. The crystallization of membrane proteins is quite a complex process and even more challenging if they are human. So far only three human membrane proteins have been structurally characterized. The team carried out experiments at the ESRF to screen crystals several times before finally being able to determine the 3D structure.
Membrane proteins- an open door to new pharmaceuticals
The new results can lead the way for the development of new and more effective medications against other diseases. Some 40 % of the proteins of interest for pharmaceutical developments are membrane proteins. (SOURCE?)
Until now detailed structural information on these proteins has been absent, and therefore it has been difficult to fully understand their function. The present study is likely to lead the way for the determination of structures of other human membrane proteins. Unravelling the secrets of more membrane protein structures will help understand fundamental processes that take place in the cell membranes.
Montserrat Capellas | alfa
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences