Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Coming Soon: Protein Synthesis Without Amino Acids?

19.07.2007
Polypeptide synthesis done differently: cobalt-catalyzed copolymerization of imines and CO

Usually, the synthesis of short protein chains (polypeptides) begins with the production of their components, the amino acids. But it can be done differently: In the journal Angewandte Chemie, Chinese researchers report a considerably more convenient method that is similar to olefin polymerization, which is used for the mass production of plastics such as polyethylene. The advantage of this reaction is that it uses inexpensive starting materials and would be ideal for industrial production.

Whether in the body or the factory, the backbone of polypeptide chains is usually formed by the linking of an amino group with the acid group of individual amino acids. Like pearls on a string, the amino acids then line up. However, to get to such a structure, it isn’t absolutely necessary to start from amino acids. Imines, compounds with a carbon-nitrogen double bond, could be an ideal starting material—if it were possible to link them together in an alternating fashion with a carbon monoxide molecule (CO), like a pearl necklace made of two different alternating types of pearl. This long-envisioned process is modeled after the plastic production process known as Ziegler-Natta polymerization, which requires special metal catalysts. The heart of this process is a step called insertion, in which the next “pearl”, or monomer, squeezes itself in between the metal atom and the growing chain.

Until now, attempts to use this type of copolymerization for peptide synthesis have failed because of the lack of a suitable, effective, and continuously operating catalyst. Researchers led by Huailin Sun at Nankai University in China have now found a catalyst to do the job: a simple cobalt complex. The team was thus able to use this technique to synthesize polypeptides that have previously not been accessible by other means.

... more about:
»Polypeptide »acid »amino acid

As a next step, the Chinese researchers want to include not just one, but a variety of imines into the same chain.

Author: Huailin Sun, Nankai University, Tianjin (China), mailto:sunhl@nankai.edu.cn

Title: Metal-Catalyzed Copolymerization of Imines and CO: A Non-Amino Acid Route to Polypeptides

Angewandte Chemie International Edition 2007, 46, No. 32, doi: 10.1002/anie.200700646

Huailin Sun | Angewandte Chemie
Further information:
http://pressroom.angewandte.org

Further reports about: Polypeptide acid amino acid

More articles from Life Sciences:

nachricht Good preparation is half the digestion
15.11.2018 | Max-Planck-Institut für Stoffwechselforschung

nachricht How the gut ‘talks’ to brown fat
16.11.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

UNH scientists help provide first-ever views of elusive energy explosion

16.11.2018 | Physics and Astronomy

How the gut ‘talks’ to brown fat

16.11.2018 | Life Sciences

Massive impact crater from a kilometer-wide iron meteorite discovered in Greenland

15.11.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>