Because of their similarity to patient tumors, these models are an exceptional tool for testing the efficacy of new drugs, adapting treatments to tumor characteristics, unraveling resistance to certain treatments, and as a result limiting the need for clinical trials in patients. Institut Curie and Inserm medical oncologists, surgeons, pathologists and biologists collaborated on this work on mouse models which can now be extended to other types of cancers. The 25 breast tumor models are described in a study published in the 1 July 2007 issue of Clinical Cancer Research.
To help clinicians in their search for more effective treatments, Marie-France Poupon and her team in Institut Curie Inserm Unit 612 “Genotoxicology, signaling and experimental radiotherapy” have developed the largest ever series of human breasts cancers grafted into mice. This six-year study would not have been successful without close collaboration between Institut Curie and Inserm medical oncologists, surgeons, pathologists, and biologists.
These breast cancer xenografts in mice reproduce the genetic, genomic, and histological characteristics of the patient-derived tumor tissues. So they recapitulate features of the original tumors, such as overexpression of HER2 receptors, absence or presence of estrogen receptors, mutation of P53, and react identically to chemotherapy.
Twenty-five models of breast tumors in mice of different biological profiles have been established. These models are an excellent preclinical research tool and can be used to test the efficacy of new drugs and novel therapeutic combinations, as well as analyze the response to treatment and adapt it to the tumor characteristics. This will help in the design of clinical trials and hasten the development of new treatments.
This work is continuing within the framework of the creation of a Preclinical Investigation Laboratory in the Translational Research Department at the Institut Curie, with a view to extending this series of tumor models to other types of cancers, such as pediatric cancers, melanoma, lung cancer, ovarian cancer, and cancers of the bronchi, prostate, and colon.
Breast cancer is the most frequent cancer in women and affects one in ten women in the developed world. Every year in France there are 42 000 new cases. Between 1980 and 2000, the number of cases increased by almost 60%, largely as a result of increasingly efficient detection and because people are living longer. Breast cancer is most commonly detected in women aged between 50 and 69 years of age (half of all cases), but can occur at any age, albeit very rarely before the age of 25.
Mortality has declined because of earlier detection and improved treatments combining surgery, radiotherapy, and chemotherapy, depending on the tumor characteristics. When the diagnosis is made early enough, conservative surgery is possible: the tumor is removed and the breast conserved. When the tumor is larger, or is accompanied by extensive precancerous lesions, it is sometimes essential to remove the breast (mastectomy).
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
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A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
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