VIB researchers connected to Ghent University have demonstrated that the caspase-14 protein - whose function has been unknown up to now - not only plays a role in maintaining the balance of moisture in the skin but also offers protection against UVB rays. Future strategies that increase the production of caspase-14 will open new possibilities for fortifying the skin as a barrier against all kinds of stress.
Sunbathing and the pernicious consequences for our skin
Sunlight is needed for the development of our bodies and minds. Still, we should not expose ourselves to it too often. The UV index provides an indication of the true intensity of the sun’s rays and the risks that go along with them.
UV rays cause functional alterations in the most important components of our skin: the keratinocytes. In addition to causing normal sunburn and suppressing our immune responses, UVB damages the DNA in our cells, which can lead to cancer. In the last 15 years, the number of new cases of melanoma (the most dangerous skin cancer in Belgium) has practically doubled to 1500 cases per year.
Caspases are proteins that are involved in inflammation reactions and in programmed cell death or apoptosis. Apoptosis is important in all stages of life. During embryonal development, for example, apoptosis ensures that undesirable or outmoded tissues disappear. In the mid-1990s, Peter Vandenabeele and his colleagues were able to isolate 9 caspase family members in mice. The properties and substrates of a number of caspases are already known. However, caspase-14 is a maverick in that it is found very specifically in the skin and is activated during the last stage of skin cell maturation. Due to the action of caspase-14, the outer epidermis of our skin contains dead cells that are released as flakes of skin.
Mice as model
To investigate the function of caspase-14, Geertrui Denecker and colleagues, under the direction of Wim Declercq and Peter Vandenabeele, developed knock-out mice that could no longer produce the protein. The shiny and lichenified skin of mice without caspase-14 is a sign that the composition of the skin’s epidermis has been altered. The lack of caspase-14 causes defects in the processing of a protein that plays a major role in maintaining the skin’s structure and balance of moisture, which can explain the skin’s dehydration.
But one of our skin’s most important functions is to protect us against UVB radiation. The researchers in Ghent have found that the filtering action of the epidermis of mice without caspase-14 decreases dramatically.
The skin as barrier
The absence of caspase-14 has very harmful effects on the skin’s protective barrier function, which results in loss of water and diminished protection against UVB. This research sheds light on a portion of the mechanisms that operate in the skin’s epidermis. The identification of molecules involved in caspase-14 dependent processes could well be important to the pharmaceutical industry, which is always seeking agents that prevent sunburn and ageing of the skin.
Ann Van Gysel | alfa
Protein interaction helps Yersinia cause disease
21.08.2018 | Schwedischer Forschungsrat - The Swedish Research Council
Nanobot pumps destroy nerve agents
21.08.2018 | American Chemical Society
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
21.08.2018 | Power and Electrical Engineering
21.08.2018 | Life Sciences
21.08.2018 | Medical Engineering