Mitosis is irreversible, only leading either to correct cell division or to genomically instable G1 cells, prone to cell death. The work of Dr. Rob Wolthuis was published in PLoS Biology, May issue.
Cyclin B1-Cdk1 activation is controlled in many ways, but once its activity rises above a certain level, further activation of Cyclin B1-Cdk1 is catalyzed by a positive-feedback loop. This triggers the start of mitosis. It is therefore critical to understand how Cyclin B1-Cdk1 can switch from an inactive to an active state. So far, no methods were available to measure how Cyclin B1–Cdk1 activity progresses in human cells over time.
Wolthuis his work combines activation measurements with a kinetic model to study how Cyclin B1-Cdk1 activity accumulates just before and during mitosis in human cells. He discovered that once Cyclin B1-Cdk1 activation is truly launched, it is bound to continue and will not lightly drop back again. Also different activity levels are required for initiation of, and progression through, mitosis.
On the basis of the findings, Wolthuis proposes that the successive Cyclin B1–Cdk1 activity levels by themselves may coordinate the progression through the distinct phases of the cell division process.
Frederique Melman | alfa
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences