Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study of damaged gene gives insight into causes of mental illness

03.05.2007
Scientists have pinpointed how different types of damage to the same gene can cause some people to suffer from schizophrenia while others have major depression

Scientists have pinpointed how different types of damage in types of damage to the same gene can cause some people to suffer from schizophrenia while others have major depression.

The findings which are published in the journal Neuron, provide further evidence that these illnesses are inherited, and may in the future help doctors pinpoint which patients will respond to different types of treatments.

Experts from the University of Edinburgh, working with researchers from Mount Sinai Hospital in Toronto, Canada and RIKEN in Japan, studied two types of damage to a gene (DISC1). Previous research at the University, working with families with a high incidence of mental illness, identified this gene as being linked to schizophrenia, manic depression (bipolar affective disorder) and major depression. The gene was also found to be essential for brain signalling and plays a key role in learning, memory and mood.

... more about:
»DISC1 »Depression »Mental »disorder »schizophrenia »types

To further their findings, experts looked at the behaviour of mice with two types of damage in the gene. The results suggest that one responded better to antipsychotics, used to treat schizophrenia while the other responded better to anti-depressants, used to treat mood disorders.

Prof David Porteous, Chair of Human Molecular Genetics and Medicine at the University of Edinburgh, said: “While the causes of schizophrenia, bipolar affective disorder and major depression are unknown, all the evidence points to subtle differences in the way the brain develops and to chemical changes in the brain. Our previous work identified the DISC1 gene as an important risk factor in these types of mental illness.

“By analysing the behaviour of mice, we were able to provide further evidence of the importance of DISC1. We also found remarkable clear cut differences between the different types of damage to the gene and the treatment that was the most effective. By analysing how the brain changes and develops over time we would hope that this would lead to more effective drugs to treat such illnesses.”

About one in 50 people worldwide will develop the symptoms of schizophrenia or bipolar affective disorder, with the first signs often appearing in late adolescence or early adulthood. Most cases arise in families with some sort of history of mental illness implying a strong influence of genes. Several different genes have been reported to pre-dispose to schizophrenia but DISC1 is one of the few which has been replicated by several laboratories.

Tara Womersley | EurekAlert!
Further information:
http://www.ed.ac.uk

Further reports about: DISC1 Depression Mental disorder schizophrenia types

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>