Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Assumption of function not always correct

03.05.2007
A protein called RecQ takes on a totally opposite function in the bacteria Escherichia coli to the one it fulfills in yeast and in humans, indicating that people seeking to understand the role of different forms in human cells and disease need to consider both possibilities, said researchers from Baylor College of Medicine in a report in the current issue of Molecular Cell.

Humans have five forms of this particular protein, and three are associated with syndromes that predispose people to cancer, said Dr. Susan Rosenberg, professor of molecular and human genetics at Baylor College of Medicine. Two of the forms are not associated with cancer syndromes.

Other organisms have forms of this protein in varying numbers, said Rosenberg. For example, E. coli has only one. All forms appear to be very similar, no matter what the organism. When proteins are found in a variety of organisms, they are called conserved.

"It was thought that because these were so well conserved, they should do more or less the same thing," said Rosenberg. However, research in her laboratory showed this was not the case.

... more about:
»Chromosome »Syndrome »intermediates »organism

In yeast and one of the human forms of a protein called RecQ actually works to help unzip DNA strands when chromosomes repair DNA damage using a process called genetic recombination. In this kind of repair, one chromosome aggregates with a partner chromosome—usually its twin chromosome following DNA replication—and then disaggregates following repair. If the repair aggregates are not unzipped, the chromosomes can't separate for reproduction. The yeast and human Werner syndrome enzymes helps prevent the buildup of unwanted intermediates of aggregated chromosomes that can actually kill the cells if not unzipped.

When that protein is lacking, the intermediates buildup and the cells die. However, while many people think all such proteins work similarly in repair, recent work by Rosenberg and others in her laboratory demonstrates that the protein works in exactly the opposite manner in E. coli.

In yeast, she said, the protein's job is to get the two chromosomes apart. One form of the protein does this also in humans, and when this protein is mutated or missing, a premature aging and cancer-predisposition disease called Werner syndrome results. Cancer results from destabilizing the chromosomes.

"When people knock out Werner (protein), they see these intermediates piling up and the cells die from failure to resolve this," she said.

Daniel B. Magner and Matthew D. Blankschien, both graduate students in Rosenberg's laboratory, found that E.coli/RecQ promotes the accumulation of these intermediates, actually promoting the cell's death by this method.

When scientists begin considering the possible of effects of other relatives of RecQ in humans and other organisms, they should be aware of this finding and consider both possibilities when seeking to link mutations in the protein to disease, said Rosenberg.

Graciela Gutierrez | EurekAlert!
Further information:
http://www.bcm.edu
http://www.molecule.org/content/article/abstract?uid=PIIS1097276507001578&highlight=magner

Further reports about: Chromosome Syndrome intermediates organism

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>