They will present the research at the 233rd national meeting of the American Chemical Society in Chicago March 25-29.
“We use visible light to signal the synthesized bioactive molecules to cleave DNA,” said Karen Brewer, professor of chemistry at Virginia Tech. “Incorporating a DNA target allows more selectivity. Coupling of the DNA targeting unit allows us to produce colored DNA-Complex assemblies that are easily photoactivated with visible light."
Avijita Jain of Bhopal, India, a Ph.D. candidate in chemistry at Virginia Tech, has designed a selective complex shown to inhibit growth in E. coli bacteria.
The group’s previous work included delivering the anticancer drug cisplatin and improved compounds to a disease site. In the process, the coupling of the drugs to the designed molecule increased water solubility. The improved selectivity along with photoinitiation reduce damage to healthy tissue.
The paper, “Synthesis, characterization, DNA binding and in vivo activity of Ru(II)/Pt(II) complexes” (INOR 690), will be presented at 1:50 p.m. Tuesday, March 27, at McCormick Place Lakeside room E253D by Jain. Co-authors are Brenda S. J. Winkel, professor of Biological Sciences at Virginia Tech, and Brewer.
Jain received her undergraduate degree from Barkatullah University Bhopal, M.P., India, and her master’s degree from Tennessee Technological University.
Aspects of DNA photocleavage ability of the new molecules will also be presented in the paper, “Coupling Ru or Os light absorbers to reactive Pt complexes: Excited state reactivity and DNA photocleavage” (INOR 1200), at 2:30 p.m., Wednesday, March 28, at McCormick Place Lakeside room E253D by Virginia Tech Ph.D. chemistry student Ran Miao of Zhangzhou City, China. Co-authors are chemistry graduate students David F. Zigler of Sterling, Illinois, and Jared Brown of Salem, Va., and Brewer.
Susan Trulove | EurekAlert!
A new molecular player involved in T cell activation
07.12.2018 | Tokyo Institute of Technology
News About a Plant Hormone
07.12.2018 | Julius-Maximilians-Universität Würzburg
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
06.12.2018 | Event News
03.12.2018 | Event News
28.11.2018 | Event News
07.12.2018 | Life Sciences
07.12.2018 | Materials Sciences
07.12.2018 | Physics and Astronomy