They have succeeded in making whole mouse brains transparent and then to reconstruct parts of their neuronal networks with a computer. During their investigations at the MPI of Psychiatry they put mouse brains in an oil solution which rendered the brains completely transparent, as now published in Nature Methods. They transilluminated these transparent brains with a laser from the side layer by layer. This way, green fluorescence was induced in genetically marked nerve cells.
Using the many images from their “ultramicroscope” the scientists in the research group of the medical doctor and physicist Hans-Ulrich Dodt were able to reconstruct parts of the neuronal network in three dimensions, comparable to computer tomography but with much higher resolution.
Prof. Dodt who was appointed to the chair of Bioelectronics of the TU Vienna in January, plans to utilize this method to investigate the complex neuronal networks of the cortex. The scientists are interested to see if it is possible to visualize alterations at nerve cells after learning using this method. Ultramicroscopy will also be used to investigate the development of neuronal diseases like Alzheimer`s in mice. Besides science, the technique also has an aesthetic aspect: One can simulate a fly-through the brain using the recorded data. Therefore in the future the technique of the glass brain will be used probably for teaching students employing a “Playstation Brain”.
Werner Sommer | alfa
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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