MAP4K3 is one of the mitogen-activated protein (MAP) kinases: serine/threonine-specific protein kinases that respond to extracellular stimuli (mitogens) and regulate various cellular activities, such as gene expression, mitosis, differentiation, cell survival and apoptosis.
mTOR (mammalian target of rapamycin) is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. It combines input from multiple upstream pathways, including insulin, growth factors and mitogens while functioning as a sensor of cellular nutrient and energy levels and redox status. Its malfunction is implicated in various human diseases, especially types of cancer.
The paper, by Greg Findlay, Lijun Yan, Julia Procter, Virginie Mieulet and Richard Lamb is published in the Biochemical Journal and is now available: http://www.biochemj.org/bj/403/bj4030013.htm, with an associated commentary http://www.biochemj.org/bj/403/bj403e001.htm. It reveals that MAP4K3 plays an important part in mTOR function and could be a target for drug intervention in tumour growth.
Professor George Banting, Chair of the Editorial Board, said "The importance of this paper is that we now have a 'way in' to the mTOR signalling pathway which is regulated by amino acids, but not by growth factors, such as insulin/IGF1. Inhibitors of MAP4K3 should switch off mTOR and so inhibit cell growth and proliferation. This is very exciting."
Mark Burgess | alfa
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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