Shulamit Michaeli and colleagues describe a pathway in T. brucei parasites that they named SLS (SL-RNA silencing). Triggering this pathway shuts down the synthesis of a crucial RNA molecule, which halts the production of messenger RNAs and leads to the parasite’s death.
Inducing SLS could therefore be a novel way to eradicate parasites and prevent sleeping sickness - trypanosomiasis. The researchers also believe this could have implications for related parasites and diseases, such as Leishmania and leishmaniasis and Trypanosoma cruzi and Chagas disease.
Sleeping sickness affects humans and livestock, and is endemic in sub-Saharan Africa where it is estimated to affect as many as 70,000 people. Leishmaniasis is estimated to affect millions of individuals throughout the world, and can lead to skin lesions, tissue damage, fever, blindness and death.
Chagas disease affects 16-18 million people across the Americas, and can cause intestinal complications, neurological disorders, heart damage and death. Although drugs are available to treat these diseases, their use is hampered by toxicity and undesirable side effects, difficulties in administering treatment, an increase in drug resistance, and high costs.
From a plant sugar to toxic hydrogen sulfide
19.12.2018 | Universität Konstanz
Gut microbiome regulates the intestinal immune system, researchers find
19.12.2018 | Brown University
Different eras of civilization are defined by the discovery of new materials, as new materials drive new capabilities. And yet, identifying the best material...
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
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19.12.2018 | Life Sciences