Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Epigenetics Could Lead to Better Cancer Diagnosis

26.02.2007
DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA’s four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off.

DNA methylation patterns differ dramatically between healthy and diseased tissue and thereby can serve as biomarkers, opening a window into earlier detection of disease. In a special issue of the journal Disease Markers published in February 2007, ten articles explore the details and challenges of cancer epigenetics.

Writing in the editorial, Guest Editor Martin Widschwendter (Institute for Women’s Health, University College London) emphasizes that, “The concept of early detection of tumours before they spread and become incurable, represents one of the most important challenges in reducing the impact of the growing burden of cancer worldwide…Altered patterns of DNA methylation can be detected with high sensitivity, potentially providing us with diagnostic, prognostic and predictive information, and can be reversed by appropriate drug treatment. These possibilities make cancer epigenetics a most exciting field of current translational research.”

Four articles document different epigenetic alterations in lung, prostate, ovarian and colorectal cancer. The observation of abnormal methylation in the RASSF1A gene in a broad spectrum of tumors is reviewed by Luke B. Hesson, Wendy N.Cooper and Farida Latif. Heidi Fiegl and Karim Elmasry review how DNA-methylation can form the basis for diagnostics and therapeutic monitors.

... more about:
»DNA »DNA methylation »epigenetic »methylation

Epigenetic silencing of the MGMT gene encoding a DNA repair enzyme was recently found to be of predictive value in a randomised clinical trial for newly diagnosed glioblastoma, reviewed by Peter Hau, Roger Stupp and Monika E. Hegi. The possibility of using epigenetic changes in normal tissue to predict an individuals risk of developing cancer is reviewed by Hengmi Cui.

Biostatisticians Todd A. Alonzo and Kimberly D. Siegmund provide an excellent review about various statistical approaches to analysis of the wealth of information gained by DNA methylation studies.

Finally, Craig A. Cooney discusses the recent emergence of “epigenetic epidemiology” where the causes of DNA methylations might be understood and used to direct epigenetics toward improved health and longevity.

Epigenetic Markers
Special issue of Disease Markers, Volume 23, Issues 1-2
Guest Editor: Martin Widschwendter
Table of Contents
EDITORIAL
5-methylcytosine – the fifth base of DNA: The fifth wheel on a car or a highly promising diagnostic and therapeutic target in cancer?

Martin Widschwendter

The Role of DNA Methylation in the Development and Progression of Lung Adenocarcinoma

Keith M. Kerr, Janice S. Galler, Jeffrey A. Hagen, Peter W. Laird, and Ite A. Laird-Offringa

Epigenetic markers for molecular detection of prostate cancer
Vera L. Costa, Rui Henrique & Carmen Jerónimo
Epigenetic Markers and Response to Chemotherapy in Cancer
Gordon Strathdee
DNA Methylation in Colorectal Cancer – impact on screening and therapy monitoring modalities ?

Marion Zitt, Matthias Zitt and Hannes M. Müller

The role of Rassf1a methylation in cancer
Luke B. Hesson, Wendy N.Cooper and Farida Latif
Cancer diagnosis, risk assessment and prediction of therapeutic response by means of DNA methylation markers

Heidi Fiegl and Karim Elmasry

MGMT methylation status : the advent of stratified therapy in glioblastoma?
Peter Hau, Roger Stupp, and Monika E. Hegi
Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer
Hengmi Cui
Statistical methods for evaluating DNA methylation as a marker for early detection or prognosis

Todd A. Alonzo and Kimberly D. Siegmund

Epigenetics – DNA-Based Mirror of Our Environment?
Craig A. Cooney

Astrid Engelen | alfa
Further information:
http://www.iospress.nl

Further reports about: DNA DNA methylation epigenetic methylation

More articles from Life Sciences:

nachricht A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Metamolds: Molding a mold

20.08.2018 | Information Technology

It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

20.08.2018 | Power and Electrical Engineering

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>