Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transdermal vaccine effective in treating Alzheimer's disease in mouse model

24.01.2007
May offer promise of skin patch or cream for treating dementia

University of South Florida researchers report that a novel needle-free vaccine approach is effective and safe in clearing brain-damaging plaques from a mouse model of Alzheimer's disease. The transdermal, or across the skin, vaccination, may offer a simpler way of preventing or treating the devastating neurodegenerative disease with less likelihood of adverse immune reactions.

The study was published online this week in The Proceedings of the National Academy of Sciences.

"While many groups have shown vaccinating against the beta amyloid protein (Ab) can reduce Alzheimer's-like pathology including certain cognitive deficits, this study is the first to demonstrate that immunization using the skin may be an effective way to reduce Ab pathology," said senior study author Jun Tan, PhD, MD, director of the Neuroimmunology Laboratory at the Institute for Research in Psychiatry, USF Department of Psychiatry.

... more about:
»Alzheimer' »immune cell »treating

"The beauty is that something as simple and non-invasive as a skin patch could potentially be a promising therapy for Alzheimer's disease," said study coauthor Terrence Town, PhD.

The Alzheimer's vaccine works by triggering the immune system to recognize Ab -- a protein that abnormally builds up in the brains of Alzheimer's patients – as a foreign invader and attack it.

Previous research on an injectable Alzheimer's vaccine proven safe and effective in an animal model was suspended indefinitely when the initial clinical trial caused brain inflammation and death in a small percentage of patients. These serious side effects were secondary to an autoimmune reaction, which occurred when immune cells aggressively attacked the body's own proteins produced by the vaccine.

The USF researchers targeted the skin as the route of vaccine delivery in mice bred to develop age-related brain degeneration mimicking Alzheimer's. They found that transdermal immunization with Ab does not appear to trigger specific toxicities associated with past immunization strategies.

Specialized immune cells prevalent in the skin, called Langerhans, may direct the body's reaction to the vaccine toward a response that is beneficial instead of overly aggressive and ultimately harmful, Dr. Tan said.

The USF researchers plan to further test whether the transdermal vaccine can curb memory loss in Alzheimer's mice as well as reduce their "senile" plaque burden. "If those studies show clear cognitive benefits," Dr. Tan said, "we believe clinical trials to evaluate a beta amyloid skin patch or topical cream in patients with Alzheimer's would be warranted."

Anne DeLotto Baier | alfa
Further information:
http://www.health.usf.edu

Further reports about: Alzheimer' immune cell treating

More articles from Life Sciences:

nachricht O2 stable hydrogenases for applications
23.07.2018 | Max-Planck-Institut für Chemische Energiekonversion

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

The Maturation Pattern of the Hippocampus Drives Human Memory Deve

23.07.2018 | Science Education

FAU researchers identify Parkinson's disease as a possible autoimmune disease

23.07.2018 | Health and Medicine

O2 stable hydrogenases for applications

23.07.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>