Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD researchers discover internal compass of immune cell

18.12.2006
Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered how neutrophils – specialized white blood cells that play key roles in inflammation and in the body's immune defense against bacteria – navigate to sites of infection and inflammation. These findings could potentially lead to new treatments for serious infections and inflammatory diseases in patients.

The research, reported in the December 15, 2006 issue of the journal Science, describes the elements of the "internal compass" that neutrophils use to detect and migrate towards chemoattractants, markers of infection and inflammation that are released from bacteria and inflamed tissues.

"These findings solve the long-standing puzzle of how neutrophils find their way and move toward sites of injury or infection in the body," said senior author Wolfgang Junger, Ph.D., adjunct professor of surgery at UCSD Medical Center.

His team set out to identify the key mechanisms of signal amplification that must occur in order for neutrophils to detect the low-level activating signals (chemoattractants) sent out by bacteria at injury sites. They found that neutrophils possess a built-in amplification system that is an integral part of the internal compass the cells use to locate the source of chemoattractants. At the core of the amplification system is the chemical adenosine triphosphate (ATP).

The chain of events necessary to direct the neutrophils toward its goal begins when ATP is released from the region of the cell surface closest to the source of chemoattractants. Next, ATP binds to a nucleotide receptor called P2Y2 on the cell surface, a step critical to position the cells in the direction of the source of chemoattractants.

Once this internal compass has been activated, ATP is converted by the cells to adenosine, which in turn activates A3 adenosine receptors concentrated at the front of cells, providing the signal to move toward the source of chemoattractants.

Lead authors Yu Chen, M.D., UCSD postgraduate researcher in surgery and Ross Corriden, UCSD graduate student in biomedical sciences, found that when ATP receptors were blocked, the cells became disoriented, while blocking A3 adenosine receptors slowed down the cell movement toward chemoattractants. The researchers also found that drugs which interfere with the amplification system impair cell migration to inflamed tissues.

"These findings are very important because they suggest that novel classes of anti-inflammatory drugs could be developed to prevent rheumatoid arthritis, inflammatory bowel diseases, asthma, and many other chronic inflammatory diseases," said Junger.

Conversely, drugs that boost these amplification systems and the internal compass could be used to coax neutrophils to migrate to infected wounds to improve wound healing.

Debra Kain | EurekAlert!
Further information:
http://www.ucsd.edu

Further reports about: ATP Cell UCSD adenosine amplification chemoattractants neutrophils receptor

More articles from Life Sciences:

nachricht Helping to Transport Proteins Inside the Cell
21.11.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht UNH researchers create a more effective hydrogel for healing wounds
21.11.2018 | University of New Hampshire

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First diode for magnetic fields

Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.

Electric diodes are essential electronic components that conduct electricity in one direction but prevent conduction in the opposite one. They are found at the...

Im Focus: Nonstop Tranport of Cargo in Nanomachines

Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.

Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

Helping to Transport Proteins Inside the Cell

21.11.2018 | Life Sciences

Meta-surface corrects for chromatic aberrations across all kinds of lenses

21.11.2018 | Power and Electrical Engineering

Removing toxic mercury from contaminated water

21.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>