Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Identified new genetic markers for high-risk cases of breast cancer

18.12.2006
Researchers have found that small changes in the DNA sequence of genes involved in DNA repair are associated with different breast cancer susceptibilities in women, suggesting that these differences could be used as genetic markers for higher risk cases.

Released as an advance online publication in the “Breast Cancer Research and Treatment” journal, the work can help, not only in the early detection and treatment of the disease, but also gives a better understanding of the mechanisms behind it.

DNA repair genes, as the name indicates, repair damaged DNA in a process crucial for cancer prevention. In fact, all over the body genetic mutations are constantly occurring and being fixed through several DNA repair mechanisms and so avoid the accumulation of harmful mutations that can ultimately lead to cancer. As consequence it has been suggested that problems in the body’s DNA repair mechanisms/genes can facilitate the development of cancer.

Following this idea, Sandra Costa, Fernando Schmitt and colleagues in Portugal and Spain, decided to test if it was possible to correlate different forms of four major DNA repair genes existent in the human population to different susceptibilities to breast cancer. In fact, different individuals can present small differences in the DNA sequence of a gene, as it happens, for example, with the gene for eye colour where the variations give origin to the different colours. These different DNA sequences appear as result of mutations and are called genetic polymorphisms.

... more about:
»DNA »DNA repair »Polymorphism »XRCC1 »XRCC3 »breast cancer

For this study Costa, Schmitt and colleagues analysed 285 breast cancer patients and 442 healthy controls looking at several genetic polymorphisms in four major DNA repair genes - XRCC1, XPD, RAD51 and XRCC3 - and their relationship with breast cancer incidence.

It was found that women carrying the genetic polymorphism XRCC1 399Gln and who had no family history of breast cancer, had not only less disease than healthy controls, but it was also found that disease, when it occurred, started later in life. This result suggested that XRCC1 399Gln had a protective effect against breast cancer.

On the opposite side of the spectrum, a genetic polymorphism in the XRCC3 gene - XRCC3 241Met - increased susceptibility to the disease and accelerated disease onset. Again this was only observed in women without a family history of breast cancer.

Finally, the team of researchers found that the polymorphism RAD51 135C increased the risk of breast cancer, this time in the group of women that belonged to families with previous cases of the disease. Variations in the fourth gene studied – XPD – did not show any effect in the incidence of breast cancer at least among the groups and the polymorphisms analysed in this work

Breast cancer is the most common type of cancer and the second leading cause of cancer death among women. According to the World Health Organization every year more than 1 million of people will be diagnosed worldwide with the disease, while 1 in 8 women will develop it during their lifetime. Nevertheless, nowadays, a diagnostic of breast cancer has a relatively good prognosis much due to the development of disease awareness and frequent screenings among women - especially those belonging to higher risk groups - allowing earlier detection (and treatment) of the disease

The work by Costa, Schmitt and colleagues, by suggesting that XRCC1 Arg399Gln, XRCC3 Thr241Met and RAD51 G135C can be used as markers for different cancer susceptibilities, helps not only to elucidate the mechanisms behind disease, but can be also crucial in the early identification of those high risk cases. These are interesting results for breast cancer, which by being the result of a complex interaction of inherited as well as environmental factors is still far from being understood and/or controlled.

Piece researched and written by: Catarina Amorim
(catarina.amorim@linacre.ox.ac.uk)

Catarina Amorim | alfa
Further information:
http://www.springerlink.com/content/2848708327416806/
http://www.linacre.ox.ac.uk

Further reports about: DNA DNA repair Polymorphism XRCC1 XRCC3 breast cancer

More articles from Life Sciences:

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>