Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Einstein researchers discover how a key dietary vitamin is absorbed

01.12.2006
Researchers at the Albert Einstein College of Medicine of Yeshiva University have found the mechanism by which the B vitamin folate—a crucially important nutrient—is absorbed by the intestinal tract.

Their findings, published in the December 1 issue of the journal Cell, solve a longstanding mystery as to how folates in the diet are absorbed and pave the way for a genetic test that can save the lives of infants who lack the ability to absorb folate.

“We can’t live without folate,” says Dr. I. David Goldman, the study’s senior author and director of the Albert Einstein Cancer Center. “Adequate folate in our diet --and our small intestine’s ability to absorb it -- are crucial for synthesizing DNA and other important constituents of our bodies. Folate deficiency in the developing embryo can cause developmental nervous-system defects such as spina bifida. After birth, infants with folate deficiency can experience anemia, immune deficiency with severe infections, and neurological defects such as seizures and mental retardation. And in adults, folate deficiency has been associated with an increased risk of certain cancers.”

A water-soluble vitamin such as folate can’t readily penetrate the fatty membrane of cells. It needs a specialized uptake mechanism so it can be absorbed by intestinal cells and ultimately enter the bloodstream. The Einstein researchers identified the membrane protein, dubbed PCFT/HCP1, that transports folate molecules from the small intestine’s acidic milieu into intestinal cells. A study published last year aroused considerable scientific fanfare when it reported that this protein ferried heme linked to iron (which becomes hemoglobin when coupled with the protein globin) into intestinal cells. But the Einstein study shows that folate transport is the primary function of this protein.

... more about:
»Vitamin »absorbed »deficiency »folate »intestinal

The Einstein study also showed that a mutation in the PCFT/HCP1 gene is responsible for hereditary folate malabsorption, a rare but potentially fatal disorder. Infants born with this condition must be treated with high doses of folate to prevent severe anemia and neurological problems that can be fatal or cause irreversible damage. The researchers made the link between mutations in the folate transporter gene and hereditary folate malabsorption by studying a Puerto Rican family in which two children were affected by the condition.

“Families at risk for hereditary folate malabsorption now have a genetic test that can quickly detect this condition before birth or in their newborns,” says Dr. Goldman. “Rapid diagnosis of this disease will insure that these infants will be started on folate supplementation as soon as possible after birth.”

Karen Gardner | EurekAlert!
Further information:
http://www.aecom.yu.edu

Further reports about: Vitamin absorbed deficiency folate intestinal

More articles from Life Sciences:

nachricht A new molecular player involved in T cell activation
07.12.2018 | Tokyo Institute of Technology

nachricht News About a Plant Hormone
07.12.2018 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

Im Focus: The force of the vacuum

Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.

The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

Inaugural "Virtual World Tour" scheduled for december

28.11.2018 | Event News

 
Latest News

A new molecular player involved in T cell activation

07.12.2018 | Life Sciences

High-temperature electronics? That's hot

07.12.2018 | Materials Sciences

Supercomputers without waste heat

07.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>