University of New South Wales (UNSW) academics have proven that tumours can be prevented from forming when embryonic stem cells are transplanted.
“Whilst embryonic stem cells have great potential to deliver therapies for disorders, such as diabetes, a fear has been that they will form tumours because of the presence of undifferentiated cells,” said UNSW Professor Bernie Tuch of the Diabetes Transplant Unit, who led the team responsible for the discovery.
“The passing of the legislation in the Senate last night is extremely encouraging,” said Professor Tuch. “Our breakthrough removes what could have been a stumbling block to this vital research.”
The team has shown that placing the embryonic cells inside microcapsules made from a product of seaweed, called alginate, prevents the formation of tumours when the encapsulated cells are transplanted into laboratory animals. The team has also shown that the encapsulation process does not stop the embryonic cells from differentiating.
The data describing the experiments has been published in the North American journal Transplantation, the official journal of the international Transplantation Society.
The team used both human and mouse embryonic stem cells to perform their experiments. The human embryonic stem cells were supplied by a member of the team, Chief Hospital Scientist, Dr Kuldip Sidhu, who earlier this year reported producing clones from these stem cells.
The other authors on the paper were Sophia Dean, Yulyana Yulyana and Georgia Williams.
The platform technology of microencapsulation is the same as that which the Diabetes Transplant Unit is using to transplant insulin-producing cells isolated from donor humans into insulin-dependent diabetic people, without using anti-rejection drugs. This Seaweed Diabetes Pilot Trial, which involves 6 people with diabetes, commenced in February this year and is expected to be completed within the next 18 months.
Contact details: Susi Hamilton, UNSW Media unit, 9385 1583 or 0422 934 024
Susi Hamilton | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology