Researchers from the Erasmus University in Rotterdam have demonstrated that a gene helps in the neat repair of DNA. Without this gene the body would repair damaged DNA in a careless manner more often. This causes new damage, which can lead to cancer.
The careless repair of damaged DNA can cause mutations and can result in cancer. Cell biologists from the Erasmus University in Rotterdam studied the repair of double strand breaks. Such breaks can for example arise following radiotherapy.
The researchers simulated radiotherapy by specifically damaging the DNA of mouse cells. Mouse cells in which the gene Rad54 was first inactivated, more often chose a careless means of repairing the damaged DNA. In normal mouse cells no more than 60% of the repairs are done in a careless manner, whereas in cells with an inactivated Rad54 gene this figure was about 80%.
The results show that the Rad54 gene is important for repairing breaks in a neat manner and for preventing mutations. The scientists hope that their findings combined with future research will lead to improvements in the treatment of cancer. In the meantime the researchers are examining patients who overreact to radiotherapy. The idea is that physicians could for example give milder radiotherapy to patients who lack the Rad54 gene.
Michel Philippens | alphagalileo
Numbers count in the genetics of moles and melanomas
16.08.2019 | University of Queensland
Working out why plants get sick
16.08.2019 | Institut für Pflanzenbiochemie
Soft robots have a distinct advantage over their rigid forebears: they can adapt to complex environments, handle fragile objects and interact safely with humans. Made from silicone, rubber or other stretchable polymers, they are ideal for use in rehabilitation exoskeletons and robotic clothing. Soft bio-inspired robots could one day be deployed to explore remote or dangerous environments.
Most soft robots are actuated by rigid, noisy pumps that push fluids into the machines' moving parts. Because they are connected to these bulky pumps by tubes,...
Researchers at TU Graz are working together with European partners on new possibilities of measuring vehicle emissions.
Today, air pollution is one of the biggest challenges facing European cities. As part of the Horizon 2020 research project CARES (City Air Remote Emission...
Over the next three years, researchers from the Vrije Universiteit Brussel, University of Cambridge, École Supérieure de Physique et de Chimie Industrielles de la ville de Paris (ESPCI-Paris) and Empa will be working together with the Dutch Polymer manufacturer SupraPolix on the next generation of robots: (soft) robots that ‘feel pain’ and heal themselves. The partners can count on 3 million Euro in support from the European Commission.
Soon robots will not only be found in factories and laboratories, but will be assisting us in our immediate environment. They will help us in the household, to...
Scientists at the University of Leeds have created a new form of gold which is just two atoms thick - the thinnest unsupported gold ever created.
The researchers measured the thickness of the gold to be 0.47 nanometres - that is one million times thinner than a human finger nail. The material is regarded...
An international team of scientists involving the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) in Hamburg has unraveled the light-induced electron-localization dynamics in transition metals at the attosecond timescale. The team investigated for the first time the many-body electron dynamics in transition metals before thermalization sets in. Their work has now appeared in Nature Physics.
The researchers from ETH Zurich (Switzerland), the MPSD (Germany), the Center for Computational Sciences of University of Tsukuba (Japan) and the Center for...
16.08.2019 | Event News
14.08.2019 | Event News
12.08.2019 | Event News
16.08.2019 | Life Sciences
16.08.2019 | Physics and Astronomy
16.08.2019 | Medical Engineering