Because these cells are critical in the regulation of voluntary movement, the findings, the researchers say, may lead to better therapies for neurological diseases like Parkinson's.
Led by Jack Lipton, PhD, professor of psychiatry, the study was presented today as an abstract at the Society for Neuroscience annual meeting in Atlanta.
"We're certainly not suggesting that this drug be used to treat diseases," said Lipton. "But finding new methods to enhance the survival of dopamine neurons is critical in developing new drugs for diseases such as Parkinson's.
"While MDMA itself isn't likely to be an appropriate therapy for neurodegenerative diseases, it may provide insights for developing new drugs that have similar properties.
"It's exciting to learn that an abused drug may have potential use for developing new therapeutics," he added. "It really makes you rethink your own preconceptions."
Dopamine is a neurotransmitter that has been found to regulate movement, balance, emotion and motivation, and it also affects pleasurable feelings in the brain. Researchers know that a loss of dopamine cells in the brain leads to the development of Parkinson's disease and possibly other movement disorders. Preventing dopamine cells from dying or aiding in the replacement of those cells is key to finding lasting therapies.
Lipton, director of the developmental neuroscience division in UC's psychiatry department, studies the long-term effects of abused drugs on the developing central nervous system. He noticed, during previous laboratory studies in rats, that prenatal exposure to MDMA increased growth of dopamine cells in the brain. His team then decided to study exposure to MDMA in cultured embryonic cells--where they confirmed that this drug was in fact increasing dopamine cell survival.
The findings, Lipton says, aren't consistent with what is known about adult brains, where MDMA has been shown to cause depletion of neurotransmitters--like dopamine--and has been linked to decreased brain activity.
MDMA, chemically known as methylenedioxymethamphetamine and sold and used illegally as "ecstasy," is a synthetic stimulant that prompts the secretion of large amounts of the neurotransmitters serotonin, dopamine and norepinephrine in the brain. This secretion can lead to prolonged periods of activity, hallucinations and euphoria. Before the United States banned it in 1985, MDMA was tested as a possible adjunct in psychotherapy. In 2001, the FDA agreed to allow MDMA to be tested as a possible treatment for post-traumatic stress disorder.
Dama Kimmon | EurekAlert!
Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland
Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
14.12.2018 | Power and Electrical Engineering
14.12.2018 | Physics and Astronomy
14.12.2018 | Physics and Astronomy