"These findings add to the growing evidence that GRK2 is a biomarker for heart failure," says Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia. Dr. Koch previously demonstrated that GRK2 is critically important in heart function. It is increased in failing human hearts and contributes to the loss of the heart's contractile strength during the development of heart failure.
In the current study, to be reported September 11, 2006 at the 10th Annual Scientific Meeting of the Heart Failure Society of America in Seattle, Amit Mittal, M.D., heart failure research fellow in the Department of Medicine at Jefferson Medical College, and his co-workers recruited patients at either Thomas Jefferson University Hospital when they were being treated, or during outpatient visits to their physicians. Heart failure patients who often have poor left ventricular function were compared to patients with normal left ventricular function who were taking no heart medications.
White blood cells from 20 heart failure patients were compared with white blood cells from 30 patients who didn't have heart disease to determine the presence of the GRK2 protein. "We have confirmed that GRK2 in white blood cells is elevated in human patients with failing hearts when compared to subjects with normal left ventricular function," Dr. Mittal said. "The GRK2 levels in heart failure patients were three to four times higher."
"Future studies will compare GRK2 levels in heart failure patients treated with standard prescription drug and device therapy to test our hypothesis that GRK2 can be a surrogate marker for determination of a given patient's response to treatment," Dr. Koch explains.
Nan Myers | EurekAlert!
Insect Antibiotic Provides New Way to Eliminate Bacteria
15.11.2018 | Universität Zürich
New findings help to better calculate the oceans’ contribution to climate regulation
15.11.2018 | Jacobs University Bremen gGmbH
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
15.11.2018 | Life Sciences
15.11.2018 | Materials Sciences
14.11.2018 | Materials Sciences