Their crystal structure of the large T antigen/p53 complex interaction will be featured on the September 1st cover of G&D (see accompanying image).
The Simian Virus 40 (SV40) genome encodes a large tumor antigen (LTag) protein, which is synthesized early on and is necessary for productive viral infection. Once inside a host cell, LTag interacts with the p53 and Rb tumor suppressor proteins and renders them inactive. p53 and Rb inhibition drives cells into S phase, promoting both host and viral genome replication. Owing to LTag's ability to overtake cellular growth control, and thereby induce tumors in animals, LTag is classified as a viral oncoprotein.
Dr. Chen and colleagues reveal that the LTag-p53 complex is comprised of a hexameric LTag protein bound to six p53 molecules. Their structure illustrates how p53 protein conformation changes upon LTag binding, and thereby prevents p53 binding to DNA.
Dr. Chen explains that "The X-ray structure provides a molecular explanation for the oncogenesis potential of the virus oncoprotein LTag. LTag induces the conformational change of p53 protein through physical interactions. By doing so, LTag abolishes the tumor suppressor function of p53, which can lead to genomic instability and tumor formation".
Heather Cosel | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences