Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Microscopic scaffolding offers a ‘simple’ solution to treating skin injuries

28.06.2006
A revolutionary dissolvable scaffold for growing new areas of skin could provide a safer, more effective way of treating burns, diabetic ulcers and similar injuries.

This ultra-fine, 3-dimensional scaffold, which is made from specially developed polymers, looks similar to tissue paper but has fibres 100 times finer. Before it is placed over a wound, the patient’s skin cells (obtained via a biopsy (1)) are introduced and attach themselves to the scaffold, multiplying until they eventually grow over it. When placed over the wound, the scaffold dissolves harmlessly over 6 to 8 weeks, leaving the patient’s skin cells behind.

This new approach to skin reconstruction has been developed by a team of chemists, materials scientists and tissue engineers at the University of Sheffield, with funding from the Engineering and Physical Sciences Research Council. It is designed primarily for cases involving extensive burns where surgeons are unable to take enough skin grafts from elsewhere on the body to cover the damaged areas. Currently, bovine collagen (2) or skin from human donors is used in these cases, but these approaches have potential health and rejection risks.

“Simplicity is the key,” says Professor Tony Ryan, who is leading the team. “Previous attempts to find better ways of encouraging skin cell growth have used chemical additives and other elaborate techniques to produce scaffolds, but their success has been limited. We’ve found that skin cells are actually very ‘smart’ – it’s in their DNA to sort themselves into the right arrangement. They just need a comparatively uncomplicated scaffold (and each other) to help them grow in a safe, natural way.”

The polymers used in the scaffold are biodegradable materials already approved for medical applications. Because the team has recognised that skin cells are ‘smart’ and the scaffold can therefore be ‘dumb’ (i.e. not overly sophisticated), simple polymers can be used.

The process for making the scaffolds is based on the well-known technique of electrospinning (3). However, the team has made a key advance by developing a new method of making, from the same biodegradable polymers, aligned-fibre ‘mats’ of potential use in promoting nerve or tendon growth. This method is currently being patented.

The next step in the research is to develop the skin reconstruction technology for clinical use, hopefully in the next few years. The technology also offers possibilities for testing the toxicity of cosmetic and similar products, using materials grown in the laboratory that closely resemble natural skin.

“Ultimately, we can envisage treatment of burns victims and the undertaking of reconstructive surgery using the scaffold and the patient’s own skin to produce bespoke skin for that patient,” says Professor Ryan. “As an accident-prone mountain biker, I find that prospect very attractive!”

1- A biopsy is the removal of a sample of tissue from a living person.

2- Bovine collagen is a fibrous protein found in cow’s skin.

3- Electrospinning is a technique for producing polymer fibres down to nano-scale and involves use of an electrostatic field.

Natasha Richardson | alfa
Further information:
http://www.epsrc.ac.uk/

More articles from Life Sciences:

nachricht Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland

nachricht Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>