The research sheds new light on understanding this molecular mechanism and is likely to aid in research on diseases involving DNA damage, including cancer.
Protein (green dot) shown in this sequence scanning through a cell’s DNA for mutations.
An article regarding the work of the Hebrew University researchers appears in the current issue of the scientific journal Cell.
The researchers, headed by Dr. Sigal Ben-Yehuda of the Department of Molecular Biology at the Hebrew University-Hadassah Medical School, revealed a new protein which scans DNA at the onset of bacterial sporulation. The protein moves quickly along the chromosome and identifies DNA damage. When the protein identifies such damage, it halts at that spot and signals to other proteins which repair DNA.
Under conditions of stress, some bacteria undergo a process of division which produces spores. These spores are particularly resistant to conditions of heat, radiation, dryness and exposure to chemicals, making it difficult to eradicate them with conventional methods, such as antibiotic drugs.
Most of the knowledge about sporulation of bacteria has been gathered over the years on a bacterium known as Bacillus subtilis, a bacterium which does not cause any illnesses. When this bacterium enters the sporulation phase, it verifies that the DNA sequence is in proper order and does not contain any mutations. But the process of how this occurs has not been observed until now.
“For the first time it is now possible to see how this phenomenon occurs,” said Dr. Ben-Yehuda. “Proteins triggered by the bacteria that are similar to the protein that has been revealed in our laboratory are found in all species, including humans, and therefore one can conclude that the way in which the bacterial protein scans the DNA for lesions is similar among many forms of life.
“This understanding of the molecular basis of the DNA repair is a basic step in furthering our ability to understand those illnesses stemming from DNA damage, for example cancerous growths. “
Jerry Barach | alfa
During HIV infection, antibody can block B cells from fighting pathogens
14.08.2018 | NIH/National Institute of Allergy and Infectious Diseases
First study on physical properties of giant cancer cells may inform new treatments
14.08.2018 | Brown University
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences