Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Altering genetic blueprint of receptors in brain could help stroke victims avoid brain damage

12.04.2006
A University of Central Florida researcher has demonstrated that altering AMPA receptors in animals improved their chances of surviving strokes and remaining healthier afterwards.

A University of Central Florida researcher has discovered that altering a receptor that mediates communication between nerve cells in the brain significantly improves animals’ chances of surviving strokes and allows them to remain healthier afterwards.

YouMing Lu, a professor at the UCF Burnett College of Biomedical Sciences, is hopeful that changing the genetic blueprint of AMPA receptors can help to block lethal flows of calcium into neurons of human stroke victims.

If administered within a few hours of cardiac arrest, such therapies could prevent brain damage. Given later, the therapies could speed up the regeneration of neurons to replace ones killed by the stroke. In both cases, the primary goal is to help patients avoid brain injuries after strokes.

AMPA receptors that are located at the surface of nerve cells are normally responsible for learning and memory formation. During strokes, however, the receptors become toxic to nerve cells.

"We’re trying to find out what the major toxic aspects of these receptors are so we can rescue neurons without damaging learning and memory formation," Lu said.

Lu’s research was published in the March 2 issue of Neuron, a prestigious biomedical research journal. Lu and his research team at UCF and the University of Calgary are trying to determine the molecular functions that lead to receptors opening up and enabling large, lethal flows of calcium to reach neurons after strokes.

The calcium flows occur in the hippocampus of the brain, an area that is critical for learning and memory processes. The dilemma for researchers is to figure out how to protect neurons from the lethal doses of calcium without causing more damage to learning and memory.

Lu’s approach of modifying one part of the genetic blueprint of the AMPA receptor protected the brain in tests with mice and rats, which experience the same pattern of brain damage after cardiac arrest as humans do, Lu said. More tests in animals would be done before clinical trials are conducted.

Lu conducted his research with funds from the American Heart Association, plus other grants from the UCF presidential equipment fund, the Heart and Stroke Foundation of Canada and the Canadian Institute for Health Research. Lu’s research has potential future applications for Alzheimer’s disease and other neurological illnesses. Drug therapies for those diseases also could improve learning and memory by inducing the regeneration of neurons.

Lu began his research about six years ago at the University of Calgary. He moved to the University of Central Florida 1 1/2 years ago, when the university began hiring more faculty members in the Burnett College of Biomedical Sciences to develop a foundation for a new medical college at UCF.

Chad Binette | EurekAlert!
Further information:
http://www.ucf.edu

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>