The allosteric, or antiterminator, model proposes that transcription of the poly(A) site triggers conformational changes that destabilize the elongating RNA polymerase, resulting in termination. The torpedo model proposes that an exonuclease degrades the nascent RNA, and eventually catches up to the elongation complex, causing its termination.
Using a novel experimental system to study the function of the exonuclease Rat1 in yeast, Dr. Bentley’s team now shows that while the exonucleases Rat1 and Xrn1 do degrade the nascent RNA transcript, this degradation is not sufficient to cause polymerase termination. Rather, Rat1 helps recruit cleavage and polyadenylation factors that are necessary for termination. "As is often the case with competing hypotheses like the torpedo and allosteric models for transcription termination, neither one can explain the whole story, but aspects of both are correct, and these form the basis for a unified model," explains Dr. Bentley.
Heather Cosel | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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