Shaped by much previous research, the prevailing view regarding sex-specific differences in the brain is that they are caused by circulating sex hormones, which are generated outside the brain and influence certain aspects of brain development, as well as brain function in adults. But new findings, reported by a team including Dr. Eric Vilain of UCLA, now reveal a new dimension to the influence of sex determination on brain function. The research shows that a single sex-specific gene plays a direct role in the brain by acting in neurons themselves, in addition to exerting an influence on the brain from afar through the action of hormones.
The researchers show that the mammalian gene SRY, which is the key sex-determination gene that directs gonads to develop as testes rather than ovaries, is also required in males for the normal function of a particular set of neurons in the adult mouse brain. These neurons secrete the neurotransmitter dopamine in the substantia nigra, a brain region that degenerates in Parkinsons disease.
SRY is passed from father to son on the Y chromosome and is not present in females. It is particularly intriguing that a gene that acts specifically in one sex is essential for the proper function of a certain set of neurons in males.
Heidi Hardman | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
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New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
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Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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